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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4245
Target Type SINGLE PROTEIN
Preferred Name Estrogen-related receptor gamma
Synonyms ERR gamma-2 | ERR3 | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group b > nuclear hormone receptor subfamily 3 group b member 3

Target Components

Component Description Relationship Accession
Estrogen-related receptor gamma SINGLE PROTEIN P62508

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL10041 AFIMOXIFENE Estrogen-related receptor gamma antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196482
Ensembl ENSG00000196482
GO Cellular Component GO:0005654 (nucleoplasm)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0003708 (retinoic acid receptor activity)
GO:0005496 (steroid binding)
GO:0008270 (zinc ion binding)
GO:0016563 (transcription activator activity)
GO:0043565 (sequence-specific DNA binding)
GO:0050682 (AF-2 domain binding)
GO Biological Process GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0010467 (gene expression)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0045893 (positive regulation of transcription, DNA-templated)
Wikipedia Estrogen-related_receptor_gamma

Target Cross References - Protein

canSAR P62508
Human Protein Atlas ENSG00000196482
IntAct P62508
PharmGKB PA27891
UniProt A8K4I0 A8K6I2 O75454 O96021 P62508 Q68DA0 Q6P274 Q6PK28 Q6TS38 Q9R1F3 Q9UNJ4

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR003078 (Retinoic_acid_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
IPR024178 (Oest_rcpt/oest-rel_rcp.)
IPR027289 (Oest-rel_rcp.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1KV6 1S9P 1S9Q 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC
CREDO 1KV6 1S9P 1S9Q 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC
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