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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4237
Target Type SINGLE PROTEIN
Preferred Name Ribosomal protein S6 kinase alpha 5
Synonyms 90 kDa ribosomal protein S6 kinase 5 | MSK1 | Nuclear mitogen- and stress-activated protein kinase 1 | RPS6KA5 | RSK-like protein kinase | RSKL | Ribosomal protein S6 kinase alpha-5 | S6K-alpha-5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase mskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase msk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-5 SINGLE PROTEIN O75582

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100784
Ensembl ENSG00000100784
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0035175 (histone kinase activity (H3-S10 specific))
GO:0046872 (metal ion binding)
GO Biological Process GO:0001818 (negative regulation of cytokine production)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007411 (axon guidance)
GO:0016310 (phosphorylation)
GO:0016572 (histone phosphorylation)
GO:0032793 (positive regulation of CREB transcription factor activity)
GO:0033129 (positive regulation of histone phosphorylation)
GO:0035066 (positive regulation of histone acetylation)
GO:0035556 (intracellular signal transduction)
GO:0043987 (histone H3-S10 phosphorylation)
GO:0043988 (histone H3-S28 phosphorylation)
GO:0043990 (histone H2A-S1 phosphorylation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070498 (interleukin-1-mediated signaling pathway)
Wikipedia RPS6KA5

Target Cross References - Protein

canSAR O75582
Human Protein Atlas ENSG00000100784
IntAct O75582
Guide to Pharmacology 1523
Open Targets ENSG00000100784
PharmGKB PA34849
Pharos O75582 (Tchem)
Reactome R-HSA-198753 (ERK/MAPK targets.)
R-HSA-199920 (CREB phosphorylation.)
R-HSA-375165 (NCAM signaling for neurite out-growth.)
R-HSA-437239 (Recycling pathway of L1.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
UniProt B7Z2Y5 O75582 O95316 Q96AF7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 1VZO 3KN5 3KN6
CREDO 1VZO 3KN5 3KN6
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