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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4237
Target Type SINGLE PROTEIN
Preferred Name Ribosomal protein S6 kinase alpha 5
Synonyms 90 kDa ribosomal protein S6 kinase 5 | MSK1 | Nuclear mitogen- and stress-activated protein kinase 1 | RPS6KA5 | RSK-like protein kinase | RSKL | Ribosomal protein S6 kinase alpha-5 | S6K-alpha-5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase mskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase msk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-5 SINGLE PROTEIN O75582

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100784
Ensembl ENSG00000100784
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007411 (axon guidance)
GO:0008063 (Toll signaling pathway)
GO:0016572 (histone phosphorylation)
GO:0033129 (positive regulation of histone phosphorylation)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0035066 (positive regulation of histone acetylation)
GO:0045087 (innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0051403 (stress-activated MAPK cascade)
GO:0070498 (interleukin-1-mediated signaling pathway)
Wikipedia RPS6KA5

Target Cross References - Protein

canSAR O75582
Human Protein Atlas ENSG00000100784
IntAct O75582
Guide to Pharmacology 1523 (ribosomal protein S6 kinase, 90kDa, polypeptide 5)
PharmGKB PA34849
Reactome REACT_11061 (Signalling by NGF.)
REACT_18266 (Axon guidance.)
REACT_6900 (Signaling in Immune system.)
UniProt O75582 O95316 Q96AF7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 1VZO 3KN5 3KN6
CREDO 1VZO 3KN5 3KN6
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