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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4235
Target Type SINGLE PROTEIN
Preferred Name 11-beta-hydroxysteroid dehydrogenase 1
Synonyms 11-DH | 11-beta-HSD1 | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11 | HSD11B1 | HSD11L | SDR26C1 | Short chain dehydrogenase/reductase family 26C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Corticosteroid 11-beta-dehydrogenase isozyme 1 SINGLE PROTEIN P28845

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542430 11-beta-hydroxysteroid dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117594
Ensembl ENSG00000117594
GO Cellular Component GO:0016020 (membrane)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0003845 (11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity)
GO:0070524 (11-beta-hydroxysteroid dehydrogenase (NADP+) activity)
GO Biological Process GO:0008202 (steroid metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0030324 (lung development)
Wikipedia 11%CE%B2-hydroxysteroid_dehydrogenase_type_1

Target Cross References - Protein

canSAR P28845
CGD Cortisone reductase deficiency
Human Protein Atlas ENSG00000117594
IntAct P28845
Guide to Pharmacology 2763 (hydroxysteroid (11-beta) dehydrogenase 1)
PharmGKB PA29476
UniProt D3DT89 B2R9Z1 P28845

Target Cross References - Domain

InterPro IPR020904 (Sc_DH/Rdtase_CS.)
IPR002198 (DH_sc/Rdtase_SDR.)
IPR002347 (Glc/ribitol_DH.)
IPR016040 (NAD(P)-bd_dom.)
Pfam PF00106 (adh_short)

Target Cross References - Structure

PDBe 1XU7 1XU9 2ILT 3BZU 3CH6 3D3E 4BB5 4C7K 2IRW 3EY4 3QQP 4HFR 4HX5 2RBE 4IJV 3BYZ 3D4N 3OQ1 3PDJ 3HFG 4IJU 4K1L 3CZR 3FRJ More...
CREDO 1XU7 1XU9 2ILT 3BZU 3CH6 3D3E 4BB5 4C7K 2IRW 3EY4 3QQP 4HFR 4HX5 2RBE 4IJV 3BYZ 3D4N 3OQ1 3PDJ 3HFG 4IJU 4K1L 3CZR 3FRJ More...
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