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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4235
Target Type SINGLE PROTEIN
Preferred Name 11-beta-hydroxysteroid dehydrogenase 1
Synonyms 11-DH | 11-beta-HSD1 | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11 | HSD11B1 | HSD11L | SDR26C1 | Short chain dehydrogenase/reductase family 26C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Corticosteroid 11-beta-dehydrogenase isozyme 1 SINGLE PROTEIN P28845

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3542430 11-beta-hydroxysteroid dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117594
Ensembl ENSG00000117594
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0003845 (11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity)
GO:0016491 (oxidoreductase activity)
GO:0070524 (11-beta-hydroxysteroid dehydrogenase (NADP+) activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0030324 (lung development)
GO:0055114 (oxidation-reduction process)
Wikipedia 11%CE%B2-hydroxysteroid_dehydrogenase_type_1

Target Cross References - Protein

canSAR P28845
CGD Cortisone reductase deficiency
Human Protein Atlas ENSG00000117594
IntAct P28845
Guide to Pharmacology 2763
Open Targets ENSG00000117594
PharmGKB PA29476
Reactome R-HSA-194002 (Glucocorticoid biosynthesis.)
UniProt B2R9Z1 D3DT89 P28845

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR016040 (NAD(P)-bd_dom.)
IPR020904 (Sc_DH/Rdtase_CS.)
Pfam PF00106 (adh_short)

Target Cross References - Structure

PDBe 1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 More...
CREDO 1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 More...
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