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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4204
Target Type SINGLE PROTEIN
Preferred Name MAP kinase signal-integrating kinase 2
Synonyms GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 | MAPK signal-integrating kinase 2 | MKNK2 | MNK2 | Mnk2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mapkapk family > camk protein kinase mnk subfamily

Target Components

Component Description Relationship Accession
MAP kinase-interacting serine/threonine-protein kinase 2 SINGLE PROTEIN Q9HBH9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883293 MAP kinase-interacting serine/threonine-protein kinase 1/2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099875
Ensembl ENSG00000099875
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016604 (nuclear body)
GO:0016605 (PML body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0009931 (calcium-dependent protein serine/threonine kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007166 (cell surface receptor signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030097 (hemopoiesis)
GO:0035556 (intracellular signal transduction)
GO:0046777 (protein autophosphorylation)
GO:0071243 (cellular response to arsenic-containing substance)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia MKNK2

Target Cross References - Protein

canSAR Q9HBH9
Human Protein Atlas ENSG00000099875
IntAct Q9HBH9
Guide to Pharmacology 2105
Open Targets ENSG00000099875
PharmGKB PA30830
Pharos Q9HBH9 (Tchem)
UniProt Q6GPI3 Q9HBH8 Q9HBH9 Q9UHR0 Q9Y2N6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2AC3 2AC5 2HW7
CREDO 2AC3 2AC5 2HW7
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