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Target Report Card

Target Name and Classification

Target ID CHEMBL4189
Preferred Name Homeobox protein Brn-2
Synonyms BRN2 | Brain-2 | Brain-specific homeobox/POU domain protein 2 | Brn-2 | Nervous system-specific octamer-binding transcription factor N-Oct-3 | OCT7 | OTF-7 | OTF7 | Oct-7 | Octamer-binding protein 7 | Octamer-binding transcription factor 7 | POU domain, class 3, transcription factor 2 | POU3F2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
POU domain, class 3, transcription factor 2 SINGLE PROTEIN P20265

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184486
Ensembl ENSG00000184486
GO Cellular Component GO:0005634 (nucleus)
GO:0005667 (transcription factor complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001105 (RNA polymerase II transcription coactivator activity)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007420 (brain development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008544 (epidermis development)
GO:0010629 (negative regulation of gene expression)
GO:0014002 (astrocyte development)
GO:0014044 (Schwann cell development)
GO:0021799 (cerebral cortex radially oriented cell migration)
GO:0021869 (forebrain ventricular zone progenitor cell division)
GO:0021979 (hypothalamus cell differentiation)
GO:0021985 (neurohypophysis development)
GO:0022011 (myelination in peripheral nervous system)
GO:0030182 (neuron differentiation)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0045595 (regulation of cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050770 (regulation of axonogenesis)
GO:0071310 (cellular response to organic substance)
Wikipedia POU3F2

Target Cross References - Protein

canSAR P20265
Human Protein Atlas ENSG00000184486
IntAct P20265
Open Targets ENSG00000184486
PharmGKB PA33539
UniProt P20265 Q14960 Q86V54 Q9UJL0

Target Cross References - Domain

InterPro IPR000327 (POU_dom.)
IPR001356 (Homeobox_dom.)
IPR009057 (Homeobox-like.)
IPR010982 (Lambda_DNA-bd_dom.)
IPR013847 (POU.)
IPR016362 (TF_POU_3.)
IPR017970 (Homeobox_CS.)
Pfam PF00046 (Homeobox)
PF00157 (Pou)