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Target Report Card

Target Name and Classification

Target ID CHEMBL4179
Preferred Name c-Jun N-terminal kinase 2
Synonyms JNK-55 | JNK2 | MAP kinase 9 | MAPK 9 | MAPK9 | Mitogen-activated protein kinase 9 | PRKM9 | SAPK1A | SAPK1a | Stress-activated protein kinase 1a | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase jnk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 9 SINGLE PROTEIN P45984

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096667 c-Jun N-terminal kinase, JNK PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1614713 CC-401 c-Jun N-terminal kinase 2 inhibitor 2 Other PubMed
CHEMBL1950289 TANZISERTIB c-Jun N-terminal kinase 2 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000050748
Ensembl ENSG00000050748
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004705 (JUN kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0008656 (cysteine-type endopeptidase activator activity involved in apoptotic process)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031435 (mitogen-activated protein kinase kinase kinase binding)
GO Biological Process GO:0001836 (release of cytochrome c from mitochondria)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006626 (protein targeting to mitochondrion)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006950 (response to stress)
GO:0007254 (JNK cascade)
GO:0007258 (JUN phosphorylation)
GO:0007417 (central nervous system development)
GO:0009612 (response to mechanical stimulus)
GO:0009636 (response to toxic substance)
GO:0010033 (response to organic substance)
GO:0010628 (positive regulation of gene expression)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010770 (positive regulation of cell morphogenesis involved in differentiation)
GO:0014075 (response to amine)
GO:0016310 (phosphorylation)
GO:0031175 (neuron projection development)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0031396 (regulation of protein ubiquitination)
GO:0032308 (positive regulation of prostaglandin secretion)
GO:0032722 (positive regulation of chemokine production)
GO:0034644 (cellular response to UV)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042493 (response to drug)
GO:0042752 (regulation of circadian rhythm)
GO:0043065 (positive regulation of apoptotic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046328 (regulation of JNK cascade)
GO:0046686 (response to cadmium ion)
GO:0048511 (rhythmic process)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071347 (cellular response to interleukin-1)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071803 (positive regulation of podosome assembly)
GO:2001235 (positive regulation of apoptotic signaling pathway)
Wikipedia Mitogen-activated_protein_kinase_9

Target Cross References - Protein

canSAR P45984
Human Protein Atlas ENSG00000050748
IntAct P45984
Guide to Pharmacology 1497
Open Targets ENSG00000050748
PharmGKB PA30630
Pharos P45984 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-450341 (Activation of the AP-1 family of transcription factors.)
UniProt A8K0S3 B5BU66 B5M0B4 D3DWQ8 D3DWQ9 P45984 Q15708 Q15710 Q15711 Q8N5C5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008351 (MAPK_JNK.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure