ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4176
Preferred Name Alpha-L-fucosidase I
Synonyms Alpha-L-fucosidase 1 | Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase 1 | FUCA1 | Tissue alpha-L-fucosidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tissue alpha-L-fucosidase SINGLE PROTEIN P04066

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179163
Ensembl ENSG00000179163
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0035578 (azurophil granule lumen)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004560 (alpha-L-fucosidase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006004 (fucose metabolic process)
GO:0006027 (glycosaminoglycan catabolic process)
GO:0008152 (metabolic process)
GO:0016139 (glycoside catabolic process)
GO:0019377 (glycolipid catabolic process)
GO:0043312 (neutrophil degranulation)
Wikipedia Fucosidase

Target Cross References - Protein

canSAR P04066
CGD Fucosidosis
Human Protein Atlas ENSG00000179163
IntAct P04066
Open Targets ENSG00000179163
PharmGKB PA28422
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-975578 (Reactions specific to the complex N-glycan synthesis pathway.)
UniProt B2RBG3 P04066 Q14334 Q14335 Q3LID0 Q8NAC2

Target Cross References - Domain

InterPro IPR000933 (Glyco_hydro_29.)
IPR013780 (Glyco_hydro_b.)
IPR016286 (FUC_metazoa-typ.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR018526 (Glyco_hydro_29_CS.)
IPR028755 (FUCA1.)
IPR031919 (Fucosidase_C.)
Pfam PF01120 (Alpha_L_fucos)
PF16757 (Fucosidase_C)