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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4175
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase CTK
Synonyms CHK | CSK homologous kinase | CTK | HYL | Hematopoietic consensus tyrosine-lacking kinase | MATK | Megakaryocyte-associated tyrosine-protein kinase | Protein kinase HYL | Tyrosine-protein kinase CTK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase csk family

Target Components

Component Description Relationship Accession
Megakaryocyte-associated tyrosine-protein kinase SINGLE PROTEIN P42679

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000007264
Ensembl ENSG00000007264
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007498 (mesoderm development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038128 (ERBB2 signaling pathway)
GO:0045087 (innate immune response)
Wikipedia Megakaryocyte-associated_tyrosine_kinase

Target Cross References - Protein

canSAR P42679
Human Protein Atlas ENSG00000007264
IntAct P42679
Guide to Pharmacology 2101
Open Targets ENSG00000007264
PharmGKB PA30649
Pharos P42679 (Tbio)
Reactome R-HSA-8863795 (Downregulation of ERBB2 signaling.)
UniProt B3KNZ9 P42679 Q9NST8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1JWO 3US4
CREDO 1JWO 3US4
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