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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4174
Target Type SINGLE PROTEIN
Preferred Name Sialidase 4
Synonyms N-acetyl-alpha-neuraminidase 4 | NEU4 | Sialidase-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Sialidase-4 SINGLE PROTEIN Q8WWR8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204099 ENSG00000277926
Ensembl ENSG00000204099 ENSG00000277926
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005764 (lysosome)
GO:0016020 (membrane)
GO:0019866 (organelle inner membrane)
GO:0043202 (lysosomal lumen)
GO Molecular Function GO:0004308 (exo-alpha-sialidase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0052794 (exo-alpha-(2->3)-sialidase activity)
GO:0052795 (exo-alpha-(2->6)-sialidase activity)
GO:0052796 (exo-alpha-(2->8)-sialidase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006516 (glycoprotein catabolic process)
GO:0006629 (lipid metabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0006689 (ganglioside catabolic process)
GO:0008152 (metabolic process)
GO:0009313 (oligosaccharide catabolic process)
GO:0016042 (lipid catabolic process)
Wikipedia NEU4

Target Cross References - Protein

canSAR Q8WWR8
Human Protein Atlas ENSG00000204099 ENSG00000277926
IntAct Q8WWR8
Open Targets ENSG00000204099 ENSG00000277926
PharmGKB PA134917116
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-4085001 (Sialic acid metabolism.)
UniProt A8K056 J3KNJ5 Q8WWR8 Q96D64

Target Cross References - Domain

InterPro IPR011040 (Sialidases.)
IPR026856 (Sialidase_fam.)
IPR026946 (Sialidase-4.)
Pfam PF13088 (BNR_2)
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