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Target Report Card

Target Name and Classification

Target ID CHEMBL4163
Preferred Name Toll-like receptor 2
Synonyms CD_antigen=CD282 | TIL4 | TLR2 | Toll-like receptor 2 | Toll/interleukin-1 receptor-like protein 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 2 SINGLE PROTEIN O60603

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885643 Toll-like receptor 1/2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137462
Ensembl ENSG00000137462
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030667 (secretory granule membrane)
GO:0030670 (phagocytic vesicle membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0035354 (Toll-like receptor 1-Toll-like receptor 2 protein complex)
GO:0042995 (cell projection)
GO:0044297 (cell body)
GO:0045121 (membrane raft)
GO:0106003 (amyloid-beta complex)
GO Molecular Function GO:0001530 (lipopolysaccharide binding)
GO:0001875 (lipopolysaccharide receptor activity)
GO:0005515 (protein binding)
GO:0008329 (signaling pattern recognition receptor activity)
GO:0035325 (Toll-like receptor binding)
GO:0038023 (signaling receptor activity)
GO:0042497 (triacyl lipopeptide binding)
GO:0042834 (peptidoglycan binding)
GO:0044877 (macromolecular complex binding)
GO:0046982 (protein heterodimerization activity)
GO:0071723 (lipopeptide binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001774 (microglial cell activation)
GO:0001775 (cell activation)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002237 (response to molecule of bacterial origin)
GO:0002374 (cytokine secretion involved in immune response)
GO:0002376 (immune system process)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006691 (leukotriene metabolic process)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007252 (I-kappaB phosphorylation)
GO:0007612 (learning)
GO:0008285 (negative regulation of cell proliferation)
GO:0009636 (response to toxic substance)
GO:0010628 (positive regulation of gene expression)
GO:0014005 (microglia development)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032289 (central nervous system myelin formation)
GO:0032493 (response to bacterial lipoprotein)
GO:0032496 (response to lipopolysaccharide)
GO:0032570 (response to progesterone)
GO:0032613 (interleukin-10 production)
GO:0032640 (tumor necrosis factor production)
GO:0032722 (positive regulation of chemokine production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0032733 (positive regulation of interleukin-10 production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032741 (positive regulation of interleukin-18 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032868 (response to insulin)
GO:0034123 (positive regulation of toll-like receptor signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0038123 (toll-like receptor TLR1:TLR2 signaling pathway)
GO:0038124 (toll-like receptor TLR6:TLR2 signaling pathway)
GO:0042495 (detection of triacyl bacterial lipopeptide)
GO:0042496 (detection of diacyl bacterial lipopeptide)
GO:0043312 (neutrophil degranulation)
GO:0045087 (innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046209 (nitric oxide metabolic process)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0050707 (regulation of cytokine secretion)
GO:0050729 (positive regulation of inflammatory response)
GO:0050765 (negative regulation of phagocytosis)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0051964 (negative regulation of synapse assembly)
GO:0070542 (response to fatty acid)
GO:0071221 (cellular response to bacterial lipopeptide)
GO:0071223 (cellular response to lipoteichoic acid)
GO:0071726 (cellular response to diacyl bacterial lipopeptide)
GO:0071727 (cellular response to triacyl bacterial lipopeptide)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:2000484 (positive regulation of interleukin-8 secretion)
Wikipedia TLR_2

Target Cross References - Protein

canSAR O60603
Human Protein Atlas ENSG00000137462
IntAct O60603
Guide to Pharmacology 1752
Open Targets ENSG00000137462
PharmGKB PA36550
Reactome R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-1461957 (Beta defensins.)
R-HSA-166058 (MyD88:Mal cascade initiated on plasma membrane.)
R-HSA-168179 (Toll Like Receptor TLR1:TLR2 Cascade.)
R-HSA-168188 (Toll Like Receptor TLR6:TLR2 Cascade.)
R-HSA-5602498 (MyD88 deficiency (TLR2/4).)
R-HSA-5603041 (IRAK4 deficiency (TLR2/4).)
R-HSA-5686938 (Regulation of TLR by endogenous ligand.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B3Y612 D1CS45 D1CS48 D1CS49 O15454 O60603 Q8NI00

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR027185 (TLR2.)
IPR032675 (LRR_dom_sf.)
IPR035897 (Toll_tir_struct_dom_sf.)
Pfam PF01463 (LRRCT)
PF01582 (TIR)
PF13855 (LRR_8)

Target Cross References - Structure

PDBe 1FYW 1FYX 1O77 2Z7X 2Z80
CREDO 1FYW 1FYX 1O77 2Z7X 2Z80