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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4163
Preferred Name Toll-like receptor 2
Synonyms CD_antigen=CD282 | TIL4 | TLR2 | Toll-like receptor 2 | Toll/interleukin-1 receptor-like protein 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Toll-like receptor 2 SINGLE PROTEIN O60603

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137462
Ensembl ENSG00000137462
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005887 (integral to plasma membrane)
GO:0035354 (Toll-like receptor 1-Toll-like receptor 2 protein complex)
GO Molecular Function GO:0001875 (lipopolysaccharide receptor activity)
GO:0004888 (transmembrane receptor activity)
GO:0042497 (triacyl lipopeptide binding)
GO:0042834 (peptidoglycan binding)
GO:0046982 (protein heterodimerization activity)
GO:0051637 (Gram-positive bacterial cell surface binding)
GO Biological Process GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006917 (induction of apoptosis)
GO:0006954 (inflammatory response)
GO:0007252 (I-kappaB phosphorylation)
GO:0008063 (Toll signaling pathway)
GO:0030177 (positive regulation of Wnt receptor signaling pathway)
GO:0032722 (positive regulation of chemokine production)
GO:0032728 (positive regulation of interferon-beta production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0032741 (positive regulation of interleukin-18 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0034123 (positive regulation of toll-like receptor signaling pathway)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0042495 (detection of triacyl bacterial lipopeptide)
GO:0042496 (detection of diacyl bacterial lipopeptide)
GO:0045087 (innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0071223 (cellular response to lipoteichoic acid)
GO:0071726 (cellular response to diacyl bacterial lipopeptide)
GO:0071727 (cellular response to triacyl bacterial lipopeptide)
Wikipedia TLR_2

Target Cross References - Protein

canSAR O60603
Human Protein Atlas ENSG00000137462
IntAct O60603
Guide to Pharmacology 1752 (TLR2)
PharmGKB PA36550
Reactome REACT_6900 (Signaling in Immune system.)
UniProt B3Y612 O15454 O60603 Q8NI00

Target Cross References - Domain

InterPro IPR000157 (Toll-Interleukin_rcpt.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR004075 (IL1_rcpt_1.)
IPR017241 (Toll-like_receptor.)
Pfam PF00560 (LRR_1)
PF01582 (TIR)

Target Cross References - Structure

PDBe 1FYW 1FYX 1O77 2Z7X 2Z80
CREDO 1FYW 1FYX 1O77 2Z7X 2Z80