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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4160
Target Type SINGLE PROTEIN
Preferred Name Cathepsin Z
Synonyms CTSZ | Cathepsin P | Cathepsin X | Cathepsin Z
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin Z SINGLE PROTEIN Q9UBR2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101160
Ensembl ENSG00000101160
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005886 (plasma membrane)
GO:0030134 (ER to Golgi transport vesicle)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0002003 (angiotensin maturation)
GO:0006508 (proteolysis)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0048208 (COPII vesicle coating)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0060441 (epithelial tube branching involved in lung morphogenesis)
Wikipedia Cathepsin_Z

Target Cross References - Protein

canSAR Q9UBR2
Human Protein Atlas ENSG00000101160
IntAct Q9UBR2
Guide to Pharmacology 2354
Open Targets ENSG00000101160
PharmGKB PA27043
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
R-HSA-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-HSA-432720 (Lysosome Vesicle Biogenesis.)
R-HSA-5694530 (Cargo concentration in the ER.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B2RC40 O75331 Q9UBR2 Q9UQV5 Q9UQV6

Target Cross References - Domain

InterPro IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR025661 (Pept_asp_AS.)
IPR033157 (Cathepsin_X.)
Pfam PF00112 (Peptidase_C1)

Target Cross References - Structure

PDBe 1DEU 1EF7
CREDO 1DEU 1EF7
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