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Target Report Card

Target Name and Classification

Target ID CHEMBL4158
Target Type SINGLE PROTEIN
Preferred Name Fatty acid synthase
Synonyms 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | 3-oxoacyl-[acyl-carrier-protein] reductase | 3-oxoacyl-[acyl-carrier-protein] synthase | Enoyl-[acyl-carrier-protein] reductase | FAS | FASN | Fatty acid synthase | Oleoyl-[acyl-carrier-protein] hydrolase | [Acyl-carrier-protein] S-acetyltransferase | [Acyl-carrier-protein] S-malonyltransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
Fatty acid synthase SINGLE PROTEIN P49327

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169710
Ensembl ENSG00000169710
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005913 (cell-cell adherens junction)
GO:0016020 (membrane)
GO:0042470 (melanosome)
GO:0042587 (glycogen granule)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004312 (fatty acid synthase activity)
GO:0004313 ([acyl-carrier-protein] S-acetyltransferase activity)
GO:0004314 ([acyl-carrier-protein] S-malonyltransferase activity)
GO:0004315 (3-oxoacyl-[acyl-carrier-protein] synthase activity)
GO:0004316 (3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity)
GO:0004317 (3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity)
GO:0004319 (enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity)
GO:0004320 (oleoyl-[acyl-carrier-protein] hydrolase activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0016295 (myristoyl-[acyl-carrier-protein] hydrolase activity)
GO:0016296 (palmitoyl-[acyl-carrier-protein] hydrolase activity)
GO:0016297 (acyl-[acyl-carrier-protein] hydrolase activity)
GO:0016491 (oxidoreductase activity)
GO:0016740 (transferase activity)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0016829 (lyase activity)
GO:0019171 (3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity)
GO:0031177 (phosphopantetheine binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0044822 (poly(A) RNA binding)
GO:0047117 (enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity)
GO:0047451 (3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity)
GO:0070402 (NADPH binding)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO:0102132 (3-oxo-pimeloyl-[acp] methyl ester reductase activity)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0006084 (acetyl-CoA metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0008152 (metabolic process)
GO:0009058 (biosynthetic process)
GO:0015939 (pantothenate metabolic process)
GO:0030879 (mammary gland development)
GO:0031325 (positive regulation of cellular metabolic process)
GO:0035338 (long-chain fatty-acyl-CoA biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0071353 (cellular response to interleukin-4)
GO:0098609 (cell-cell adhesion)
Wikipedia Fatty_acid_synthase

Target Cross References - Protein

canSAR P49327
Human Protein Atlas ENSG00000169710
IntAct P49327
Guide to Pharmacology 2608
Open Targets ENSG00000169710
PharmGKB PA28006
Reactome R-HSA-163765 (ChREBP activates metabolic gene expression.)
R-HSA-199220 (Vitamin B5 (pantothenate) metabolism.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-75105 (Fatty Acyl-CoA Biosynthesis.)
UniProt P49327 Q13479 Q16702 Q4LE83 Q6P4U5 Q6SS02 Q969R1 Q96C68 Q96IT0

Target Cross References - Domain

InterPro IPR001031 (Thioesterase.)
IPR001227 (Ac_transferase_dom.)
IPR006162 (Ppantetheine_attach_site.)
IPR009081 (PP-bd_ACP.)
IPR011032 (GroES-like.)
IPR013149 (ADH_C.)
IPR013217 (Methyltransf_12.)
IPR013968 (PKS_KR.)
IPR014030 (Ketoacyl_synth_N.)
IPR014031 (Ketoacyl_synth_C.)
IPR014043 (Acyl_transferase.)
IPR016035 (Acyl_Trfase/lysoPLipase.)
IPR016036 (Malonyl_transacylase_ACP-bd.)
IPR016039 (Thiolase-like.)
IPR016040 (NAD(P)-bd_dom.)
IPR018201 (Ketoacyl_synth_AS.)
IPR020801 (PKS_acyl_transferase.)
IPR020806 (PKS_PP-bd.)
IPR020807 (PKS_dehydratase.)
IPR020841 (PKS_Beta-ketoAc_synthase_dom.)
IPR020843 (PKS_ER.)
IPR023102 (Fatty_acid_synthase_dom_2.)
IPR029058 (AB_hydrolase.)
IPR029063 (SAM-dependent_MTases.)
IPR032821 (KAsynt_C_assoc.)
Pfam PF00107 (ADH_zinc_N)
PF00109 (ketoacyl-synt)
PF00550 (PP-binding)
PF00698 (Acyl_transf_1)
PF00975 (Thioesterase)
PF02801 (Ketoacyl-synt_C)
PF08242 (Methyltransf_12)
PF08659 (KR)
PF14765 (PS-DH)
PF16197 (KAsynt_C_assoc)

Target Cross References - Structure

PDBe 1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37
CREDO 1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37
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