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Target Report Card

Target Name and Classification

Target ID CHEMBL4147
Target Type SINGLE PROTEIN
Preferred Name CaM kinase II alpha
Synonyms CAMK2A | CAMKA | CaM kinase II subunit alpha | CaMK-II subunit alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha | KIAA0968
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk2 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type II subunit alpha SINGLE PROTEIN Q9UQM7

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097164 CaM kinase II PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070808
Ensembl ENSG00000070808
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030666 (endocytic vesicle membrane)
GO:0042734 (presynaptic membrane)
GO:0045202 (synapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0035254 (glutamate receptor binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000165 (MAPK cascade)
GO:0002931 (response to ischemia)
GO:0006468 (protein phosphorylation)
GO:0006816 (calcium ion transport)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0010666 (positive regulation of cardiac muscle cell apoptotic process)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0038166 (angiotensin-activated signaling pathway)
GO:0043547 (positive regulation of GTPase activity)
GO:0046777 (protein autophosphorylation)
GO:0046928 (regulation of neurotransmitter secretion)
GO:0048168 (regulation of neuronal synaptic plasticity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051928 (positive regulation of calcium ion transport)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:1900034 (regulation of cellular response to heat)
GO:1902108 (regulation of mitochondrial membrane permeability involved in apoptotic process)
Wikipedia CAMK2A

Target Cross References - Protein

Human Protein Atlas ENSG00000070808
IntAct Q9UQM7
Guide to Pharmacology 1555
Open Targets ENSG00000070808
PharmGKB PA90
Pharos Q9UQM7 (Tchem)
Reactome R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-442982 (Ras activation uopn Ca2+ infux through NMDA receptor.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt Q9UL21 Q9UQM7 Q9Y2H4 Q9Y352

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013543 (Ca/CaM-dep_prot_kinase-assoc.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
IPR032710 (NTF2-like_dom.)
Pfam PF00069 (Pkinase)
PF08332 (CaMKII_AD)

Target Cross References - Structure

PDBe 2VZ6 3SOA 5IG3
CREDO 2VZ6 3SOA 5IG3
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