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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4146
Target Type SINGLE PROTEIN
Preferred Name Vitamin D3 receptor-interacting protein
Synonyms ARC130 | ARC130 | Activator-recruited cofactor 130 kDa component | CRSP complex subunit 3 | CRSP3 | Cofactor required for Sp1 transcriptional activation subunit 3 | DRIP130 | DRIP130 | KIAA1216 | MED23 | Mediator complex subunit 23 | Mediator of RNA polymerase II transcription subunit 23 | Protein sur-2 homolog | SUR2 | Transcriptional coactivator CRSP130 | Vitamin D3 receptor-interacting protein complex 130 kDa component | hSur-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Mediator of RNA polymerase II transcription subunit 23 SINGLE PROTEIN Q9ULK4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111426 ETS-related transcription factor Elf-3/Vitamin D3 receptor-interacting protein (ESX/MED23) PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112282
Ensembl ENSG00000112282
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
Wikipedia CRSP3

Target Cross References - Protein

canSAR Q9ULK4
CGD Mental retardation, autosomal recessive 18
Human Protein Atlas ENSG00000112282
IntAct Q9ULK4
Open Targets ENSG00000112282
PharmGKB PA162395499
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-212436 (Generic Transcription Pathway.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
TIMBAL Sur-2
UniProt B9TX55 O95403 Q5JWT3 Q5JWT4 Q6P9H6 Q9H0J2 Q9NTT9 Q9NTU0 Q9ULK4 Q9Y5P7 Q9Y667

Target Cross References - Domain

InterPro IPR021629 (Mediator_Med23.)
Pfam PF11573 (Med23)
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