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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4145
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 9
Synonyms HD7 | HD7b | HD9 | HDAC7 | HDAC7B | HDAC9 | HDRP | Histone deacetylase 7B | Histone deacetylase 9 | Histone deacetylase-related protein | KIAA0744 | MEF2-interacting transcription repressor MITR | MITR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iia

Target Components

Component Description Relationship Accession
Histone deacetylase 9 SINGLE PROTEIN Q9UKV0

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000048052
Ensembl ENSG00000048052
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0035097 (histone methyltransferase complex)
GO Molecular Function GO:0003714 (transcription corepressor activity)
GO:0004407 (histone deacetylase activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0042826 (histone deacetylase binding)
GO:0046872 (metal ion binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001975 (response to amphetamine)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006954 (inflammatory response)
GO:0007507 (heart development)
GO:0016568 (chromatin modification)
GO:0016575 (histone deacetylation)
GO:0030182 (neuron differentiation)
GO:0030183 (B cell differentiation)
GO:0032869 (cellular response to insulin stimulus)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0042113 (B cell activation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0048742 (regulation of skeletal muscle fiber development)
GO:0051153 (regulation of striated muscle cell differentiation)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
Wikipedia HDAC9

Target Cross References - Protein

canSAR Q9UKV0
Human Protein Atlas ENSG00000048052
IntAct Q9UKV0
Guide to Pharmacology 2620
Open Targets ENSG00000048052
PharmGKB PA38377
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
UniProt A7E2F3 B7Z4I4 B7Z917 B7Z928 B7Z940 C9JS87 E7EX34 F8W9E0 O94845 O95028 Q2M2R6 Q86SL1 Q86US3 Q9UKV0

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR017320 (Histone_deAcase_II_euk.)
IPR023801 (His_deacetylse_dom.)
IPR024643 (Hist_deacetylase_Gln_rich_N.)
Pfam PF00850 (Hist_deacetyl)
PF12203 (HDAC4_Gln)
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