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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4145
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 9
Synonyms HD7 | HD7b | HD9 | HDAC7 | HDAC7B | HDAC9 | HDRP | Histone deacetylase 7B | Histone deacetylase 9 | Histone deacetylase-related protein | KIAA0744 | MEF2-interacting transcription repressor MITR | MITR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iia

Target Components

Component Description Relationship Accession
Histone deacetylase 9 SINGLE PROTEIN Q9UKV0

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000048052
Ensembl ENSG00000048052
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0035097 (histone methyltransferase complex)
GO Molecular Function GO:0003714 (transcription corepressor activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0016564 (transcription repressor activity)
GO:0016566 (specific transcriptional repressor activity)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0034739 (histone deacetylase activity (H3-K16 specific))
GO:0042826 (histone deacetylase binding)
GO:0046969 (NAD-dependent histone deacetylase activity (H3-K9 specific))
GO:0046970 (NAD-dependent histone deacetylase activity (H4-K16 specific))
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-dependent)
GO:0006954 (inflammatory response)
GO:0007507 (heart development)
GO:0030183 (B cell differentiation)
GO:0032869 (cellular response to insulin stimulus)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0045892 (negative regulation of transcription, DNA-dependent)
GO:0048742 (regulation of skeletal muscle fiber development)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
Wikipedia HDAC9

Target Cross References - Protein

canSAR Q9UKV0
Human Protein Atlas ENSG00000048052
IntAct Q9UKV0
Guide to Pharmacology 2620 (histone deacetylase 9)
PharmGKB PA38377
UniProt A7E2F3 O94845 O95028 Q2M2R6 Q86SL1 Q86US3 Q9UKV0

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR017320 (Histone_deAcase_II_euk.)
IPR023801 (His_deacetylse_dom.)
Pfam PF00850 (Hist_deacetyl)
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