ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4142
Target Type SINGLE PROTEIN
Preferred Name Fibroblast growth factor receptor 2
Synonyms BEK | CD_antigen=CD332 | FGFR-2 | FGFR2 | Fibroblast growth factor receptor 2 | K-sam | KGFR | KGFR | KSAM | Keratinocyte growth factor receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fgfr family

Target Components

Component Description Relationship Accession
Fibroblast growth factor receptor 2 SINGLE PROTEIN P21802

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111434 VEGF-receptor 2 and Fibroblast growth factor receptor 2 SELECTIVITY GROUP
CHEMBL2095217 Fibroblast growth factor receptor PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201821 PALIFERMIN Fibroblast growth factor receptor 2 agonist DailyMed PubMed
CHEMBL1946170 REGORAFENIB Fibroblast growth factor receptor 2 inhibitor Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000066468
Ensembl ENSG00000066468
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0009986 (cell surface)
GO:0016021 (integral to membrane)
GO:0060076 (excitatory synapse)
GO Molecular Function GO:0005007 (fibroblast growth factor receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008201 (heparin binding)
GO:0017134 (fibroblast growth factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001525 (angiogenesis)
GO:0001657 (ureteric bud development)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0003148 (outflow tract septum morphogenesis)
GO:0003149 (membranous septum morphogenesis)
GO:0006468 (protein phosphorylation)
GO:0007267 (cell-cell signaling)
GO:0007409 (axonogenesis)
GO:0008286 (insulin receptor signaling pathway)
GO:0008589 (regulation of smoothened signaling pathway)
GO:0009791 (post-embryonic development)
GO:0009880 (embryonic pattern specification)
GO:0010453 (regulation of cell fate commitment)
GO:0016049 (cell growth)
GO:0021847 (ventricular zone neuroblast division)
GO:0021860 (pyramidal neuron development)
GO:0030282 (bone mineralization)
GO:0030901 (midbrain development)
GO:0030916 (otic vesicle formation)
GO:0031069 (hair follicle morphogenesis)
GO:0032808 (lacrimal gland development)
GO:0035264 (multicellular organism growth)
GO:0035265 (organ growth)
GO:0035602 (fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow)
GO:0035603 (fibroblast growth factor receptor signaling pathway involved in hemopoiesis)
GO:0035604 (fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow)
GO:0035607 (fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)
GO:0040014 (regulation of multicellular organism growth)
GO:0040036 (regulation of fibroblast growth factor receptor signaling pathway)
GO:0042476 (odontogenesis)
GO:0045165 (cell fate commitment)
GO:0045787 (positive regulation of cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048286 (lung alveolus development)
GO:0048557 (embryonic digestive tract morphogenesis)
GO:0048755 (branching morphogenesis of a nerve)
GO:0051150 (regulation of smooth muscle cell differentiation)
GO:0051781 (positive regulation of cell division)
GO:0055010 (ventricular cardiac muscle tissue morphogenesis)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0060174 (limb bud formation)
GO:0060349 (bone morphogenesis)
GO:0060449 (bud elongation involved in lung branching)
GO:0060463 (lung lobe morphogenesis)
GO:0060484 (lung-associated mesenchyme development)
GO:0060501 (positive regulation of epithelial cell proliferation involved in lung morphogenesis)
GO:0060523 (prostate epithelial cord elongation)
GO:0060527 (prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)
GO:0060529 (squamous basal epithelial stem cell differentiation involved in prostate gland acinus development)
GO:0060595 (fibroblast growth factor receptor signaling pathway involved in mammary gland specification)
GO:0060601 (lateral sprouting from an epithelium)
GO:0060615 (mammary gland bud formation)
GO:0060664 (epithelial cell proliferation involved in salivary gland morphogenesis)
GO:0060667 (branch elongation involved in salivary gland morphogenesis)
GO:0060670 (branching involved in embryonic placenta morphogenesis)
GO:0060687 (regulation of branching involved in prostate gland morphogenesis)
GO:0060915 (mesenchymal cell differentiation involved in lung development)
GO:0060916 (mesenchymal cell proliferation involved in lung development)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071445 (cellular response to protein stimulus)
GO:0090263 (positive regulation of canonical Wnt receptor signaling pathway)
Wikipedia Fibroblast_growth_factor_receptor_2

Target Cross References - Protein

canSAR P21802
CGD Lacrimoauriculodentodigital syndrome; Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis; Crouzon syndrome; Jackson-Weiss syndrome; Pfeiffer syndrome; Apert syndrome; Beare-Stevenson cutis gyrata syndrome
Human Protein Atlas ENSG00000066468
IntAct P21802
Guide to Pharmacology 1809 (fibroblast growth factor receptor 2)
PharmGKB PA28128
Reactome REACT_498 (Signaling by Insulin receptor.)
REACT_9470 (Signaling by FGFR.)
UniProt B4DFC2 E7EVR6 E9PCR0 P18443 P21802 Q01742 Q12922 Q14300 Q14301 Q14302 Q14303 Q14304 Q14305 Q14672 Q14718 Q14719 Q1KHY5 Q86YI4 Q8IXC7 Q96KL9 Q96KM0 Q96KM1 Q96KM2 Q9NZU2 Q9NZU3 Q9UD01 Q9UD02 Q9UIH3 Q9UIH4 Q9UIH5 Q9UIH6 Q9UIH7 Q9UIH8 Q9UM87 Q9UMC6 Q9UNS7 Q9UQH7 Q9UQH8 Q9UQH9 Q9UQI0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR003598 (Ig_sub2.)
IPR007110 (Ig-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR016248 (Tyr_kinase_fibroblast_GF_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU More...
CREDO 1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU More...
spacer
spacer