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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4134
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-A receptor 8
Synonyms EEK | EK3 | EPH- and ELK-related kinase | EPH-like kinase 3 | EPHA8 | Ephrin type-A receptor 8 | HEK3 | KIAA1459 | Tyrosine-protein kinase receptor EEK | hEK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 8 SINGLE PROTEIN P29322

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070886
Ensembl ENSG00000070886
GO Cellular Component GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031901 (early endosome membrane)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005004 (GPI-linked ephrin receptor activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006929 (substrate-dependent cell migration)
GO:0007155 (cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0016310 (phosphorylation)
GO:0016322 (neuron remodeling)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030155 (regulation of cell adhesion)
GO:0031175 (neuron projection development)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
Wikipedia EPHA8

Target Cross References - Protein

canSAR P29322
Human Protein Atlas ENSG00000070886
IntAct P29322
Guide to Pharmacology 1828
Open Targets ENSG00000070886
PharmGKB PA27823
Pharos P29322 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt P29322 Q6IN80 Q8IUX6 Q9NUA9 Q9P269

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR020691 (EphrinA_rcpt8.)
IPR027936 (Eph_TM.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 3KUL
CREDO 3KUL
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