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Target Report Card

Target Name and Classification

Target ID CHEMBL4123
Preferred Name Neurotensin receptor 1
Synonyms High-affinity levocabastine-insensitive neurotensin receptor | NT-R-1 | NTR1 | NTRH | NTRR | NTSR1 | Neurotensin receptor type 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > neurotensin receptor

Target Components

Component Description Relationship Accession
Neurotensin receptor type 1 SINGLE PROTEIN P30989

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038478 Dopamine receptor D2L/neurotensin receptor NTS1 PROTEIN COMPLEX
CHEMBL2111438 Neurotensin receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL506981 REMINERTANT Neurotensin receptor 1 antagonist 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101188
Ensembl ENSG00000101188
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009898 (cytoplasmic side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032280 (symmetric synapse)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO:0044309 (neuron spine)
GO:0045121 (membrane raft)
GO:0045202 (synapse)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0016492 (G-protein coupled neurotensin receptor activity)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0003085 (negative regulation of systemic arterial blood pressure)
GO:0003254 (regulation of membrane depolarization)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007612 (learning)
GO:0008344 (adult locomotory behavior)
GO:0014049 (positive regulation of glutamate secretion)
GO:0014054 (positive regulation of gamma-aminobutyric acid secretion)
GO:0033993 (response to lipid)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043576 (regulation of respiratory gaseous exchange)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0051280 (negative regulation of release of sequestered calcium ion into cytosol)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051930 (regulation of sensory perception of pain)
GO:0060732 (positive regulation of inositol phosphate biosynthetic process)
GO:0070779 (D-aspartate import)
GO:0071545 (inositol phosphate catabolic process)
GO:0090238 (positive regulation of arachidonic acid secretion)
GO:0097151 (positive regulation of inhibitory postsynaptic potential)
GO:0098900 (regulation of action potential)
GO:1990123 (L-glutamate import into cell)
GO:2001259 (positive regulation of cation channel activity)
Wikipedia Neurotensin_receptor_1

Target Cross References - Protein

canSAR P30989
Human Protein Atlas ENSG00000101188
IntAct P30989
Guide to Pharmacology 309
Open Targets ENSG00000101188
PharmGKB PA31821
Pharos P30989 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P30989 Q9H4H1 Q9H4T5

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR003984 (NT_rcpt.)
IPR003985 (NT1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)