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Target Report Card

Target Name and Classification

Target ID CHEMBL4121
Target Type SINGLE PROTEIN
Preferred Name CaM kinase II beta
Synonyms CAM2 | CAMK2 | CAMK2B | CAMKB | CaM kinase II subunit beta | CaMK-II subunit beta | Calcium/calmodulin-dependent protein kinase type II subunit beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk2 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type II subunit beta SINGLE PROTEIN Q13554

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097164 CaM kinase II PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000058404
Ensembl ENSG00000058404
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030425 (dendrite)
GO:0030666 (endocytic vesicle membrane)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0043204 (perikaryon)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003779 (actin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0042803 (protein homodimerization activity)
GO:0043274 (phospholipase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0010976 (positive regulation of neuron projection development)
GO:0014733 (regulation of skeletal muscle adaptation)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0032430 (positive regulation of phospholipase A2 activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0046777 (protein autophosphorylation)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048858 (cell projection morphogenesis)
GO:0051823 (regulation of synapse structural plasticity)
GO:0051924 (regulation of calcium ion transport)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060998 (regulation of dendritic spine development)
GO:0061003 (positive regulation of dendritic spine morphogenesis)
GO:0090129 (positive regulation of synapse maturation)
GO:1900034 (regulation of cellular response to heat)
Wikipedia CAMK2B

Target Cross References - Protein

Human Protein Atlas ENSG00000058404
IntAct Q13554
Guide to Pharmacology 1556
Open Targets ENSG00000058404
PharmGKB PA91
Pharos Q13554 (Tchem)
Reactome R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-442982 (Ras activation uopn Ca2+ infux through NMDA receptor.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt A4D2K0 A4D2K1 A4D2K2 A4D2K3 A4D2K4 A4D2K5 A4D2K6 O95437 O95438 O95599 Q13554 Q9UGH7 Q9UGH8 Q9UGH9 Q9UNX0 Q9UNX7 Q9UP00 Q9Y5N4 Q9Y6F4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013543 (Ca/CaM-dep_prot_kinase-assoc.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
IPR032710 (NTF2-like_dom.)
Pfam PF00069 (Pkinase)
PF08332 (CaMKII_AD)

Target Cross References - Structure

PDBe 3BHH
CREDO 3BHH
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