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Target Report Card

Target Name and Classification

Target ID CHEMBL4101
Target Type SINGLE PROTEIN
Preferred Name cAMP-dependent protein kinase alpha-catalytic subunit
Synonyms PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pka family

Target Components

Component Description Relationship Accession
cAMP-dependent protein kinase catalytic subunit alpha SINGLE PROTEIN P17612

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094138 cAMP-dependent protein kinase (PKA) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000072062
Ensembl ENSG00000072062
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0005952 (cAMP-dependent protein kinase complex)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0031514 (motile cilium)
GO:0031588 (nucleotide-activated protein kinase complex)
GO:0031594 (neuromuscular junction)
GO:0034704 (calcium channel complex)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043234 (protein complex)
GO:0044853 (plasma membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0097225 (sperm midpiece)
GO:0097546 (ciliary base)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004691 (cAMP-dependent protein kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032403 (protein complex binding)
GO:0034237 (protein kinase A regulatory subunit binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0001707 (mesoderm formation)
GO:0001843 (neural tube closure)
GO:0002027 (regulation of heart rate)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0003091 (renal water homeostasis)
GO:0006397 (mRNA processing)
GO:0006468 (protein phosphorylation)
GO:0007596 (blood coagulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0034199 (activation of protein kinase A activity)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0042157 (lipoprotein metabolic process)
GO:0043393 (regulation of protein binding)
GO:0043457 (regulation of cellular respiration)
GO:0045667 (regulation of osteoblast differentiation)
GO:0046777 (protein autophosphorylation)
GO:0046827 (positive regulation of protein export from nucleus)
GO:0048240 (sperm capacitation)
GO:0050804 (modulation of synaptic transmission)
GO:0051447 (negative regulation of meiotic cell cycle)
GO:0051480 (regulation of cytosolic calcium ion concentration)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity)
GO:0061136 (regulation of proteasomal protein catabolic process)
GO:0070613 (regulation of protein processing)
GO:0071158 (positive regulation of cell cycle arrest)
GO:0071333 (cellular response to glucose stimulus)
GO:0071374 (cellular response to parathyroid hormone stimulus)
GO:0071377 (cellular response to glucagon stimulus)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0086064 (cell communication by electrical coupling involved in cardiac conduction)
GO:1901621 (negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)
GO:1903779 (regulation of cardiac conduction)
GO:2000810 (regulation of bicellular tight junction assembly)
Wikipedia PRKACA

Target Cross References - Protein

canSAR P17612
Human Protein Atlas ENSG00000072062
IntAct P17612
Guide to Pharmacology 1476
Open Targets ENSG00000072062
PharmGKB PA33748
Pharos P17612 (Tchem)
Reactome R-HSA-111931 (PKA-mediated phosphorylation of CREB.)
R-HSA-163358 (PKA-mediated phosphorylation of key metabolic factors.)
R-HSA-163560 (Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.)
R-HSA-163615 (PKA activation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-180024 (DARPP-32 events.)
R-HSA-194223 (HDL-mediated lipid transport.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-392517 (Rap1 signalling.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-442720 (CREB phosphorylation through the activation of Adenylate Cyclase.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5610780 (Degradation of GLI1 by the proteasome.)
R-HSA-5610783 (Degradation of GLI2 by the proteasome.)
R-HSA-5610785 (GLI3 is processed to GLI3R by the proteasome.)
R-HSA-5610787 (Hedgehog 'off' state.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-70263 (Gluconeogenesis.)
R-HSA-8853659 (RET signaling.)
R-HSA-8854518 (AURKA Activation by TPX2.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt P17612 Q32P54 Q9H2Y0 Q9NRB4 Q9NRH9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9 4UJ1 4UJ2 4UJ9 4UJA 4UJB More...
CREDO 2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9 4UJ1 4UJ2 4UJ9 4UJA 4UJB More...
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