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Target Report Card

Target Name and Classification

Target ID CHEMBL4100
Preferred Name Phospholipase C-gamma-2
Synonyms 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | PLC-IV | PLC-gamma-2 | PLCG2 | Phosphoinositide phospholipase C-gamma-2 | Phospholipase C-IV | Phospholipase C-gamma-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 SINGLE PROTEIN P16885

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197943
Ensembl ENSG00000197943
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001784 (phosphotyrosine binding)
GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004629 (phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0002092 (positive regulation of receptor internalization)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002316 (follicular B cell differentiation)
GO:0006629 (lipid metabolic process)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0007165 (signal transduction)
GO:0009395 (phospholipid catabolic process)
GO:0010468 (regulation of gene expression)
GO:0016042 (lipid catabolic process)
GO:0016055 (Wnt signaling pathway)
GO:0019722 (calcium-mediated signaling)
GO:0030168 (platelet activation)
GO:0030183 (B cell differentiation)
GO:0032237 (activation of store-operated calcium channel activity)
GO:0032481 (positive regulation of type I interferon production)
GO:0032496 (response to lipopolysaccharide)
GO:0032959 (inositol trisphosphate biosynthetic process)
GO:0035556 (intracellular signal transduction)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0043069 (negative regulation of programmed cell death)
GO:0043647 (inositol phosphate metabolic process)
GO:0050852 (T cell receptor signaling pathway)
GO:0050853 (B cell receptor signaling pathway)
GO:0051209 (release of sequestered calcium ion into cytosol)
Wikipedia PLCG2

Target Cross References - Protein

canSAR P16885
CGD Familial cold autoinflammatory syndrome 3 (PLAID); Autoinflammation, antibody deficiency, and immune dysregulation syndrome (APLAID)
Human Protein Atlas ENSG00000197943
IntAct P16885
Guide to Pharmacology 1408
Open Targets ENSG00000197943
PharmGKB PA33393
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-166016 (Toll Like Receptor 4 (TLR4) Cascade.)
R-HSA-1855204 (Synthesis of IP3 and IP4 in the cytosol.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5621480 (Dectin-2 family.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt D3DUL3 P16885 Q3ZTS2 Q59H45 Q969T5

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000909 (PLipase_C_PInositol-sp_X_dom.)
IPR000980 (SH2.)
IPR001192 (PI-PLC_fam.)
IPR001452 (SH3_domain.)
IPR001711 (PLipase_C_Pinositol-sp_Y.)
IPR001849 (PH_domain.)
IPR011992 (EF-hand-dom_pair.)
IPR011993 (PH-like_dom_sf.)
IPR016279 (PLC-gamma.)
IPR017946 (PLC-like_Pdiesterase_TIM-brl.)
IPR028381 (PLC-gamma2.)
IPR035023 (PLC-gamma_C-SH2.)
IPR035024 (PLC-gamma_N-SH2.)
IPR035723 (PLCgamma2_SH3.)
IPR035892 (C2_domain_sf.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF00168 (C2)
PF00387 (PI-PLC-Y)
PF00388 (PI-PLC-X)

Target Cross References - Structure

PDBe 2W2W 2W2X