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Target Report Card

Target Name and Classification

Target ID CHEMBL4100
Target Type SINGLE PROTEIN
Preferred Name Phospholipase C-gamma-2
Synonyms 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | PLC-IV | PLC-gamma-2 | PLCG2 | Phosphoinositide phospholipase C-gamma-2 | Phospholipase C-IV | Phospholipase C-gamma-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 SINGLE PROTEIN P16885

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197943
Ensembl ENSG00000197943
GO Cellular Component GO:0005886 (plasma membrane)
GO Molecular Function GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO Biological Process GO:0009395 (phospholipid catabolic process)
GO:0030168 (platelet activation)
GO:0035556 (intracellular signal transduction)
Wikipedia PLCG2

Target Cross References - Protein

canSAR P16885
CGD Familial cold autoinflammatory syndrome 3 (PLAID); Autoinflammation, antibody deficiency, and immune dysregulation syndrome (APLAID)
Human Protein Atlas ENSG00000197943
IntAct P16885
Guide to Pharmacology 1408 (PLCγ2)
PharmGKB PA33393
Reactome REACT_2080 (PLC-mediated hydrolysis of PIP2.)
REACT_604 (Hemostasis.)
UniProt D3DUL3 P16885 Q3ZTS2 Q59H45 Q969T5

Target Cross References - Domain

InterPro IPR000008 (C2_Ca-dep.)
IPR000909 (PLipase_C_PInositol-sp_X_dom.)
IPR000980 (SH2.)
IPR001192 (Pinositol_Phospholipase-C.)
IPR001452 (SH3_domain.)
IPR001711 (Phospholipase_C_Pinositol-sp_Y.)
IPR001849 (Pleckstrin_homology.)
IPR008973 (C2_Ca/lipid-bd_dom_CaLB.)
IPR011993 (PH_type.)
IPR015359 (Phospholipase_C_EF-hand-like.)
IPR016279 (PLC-gamma.)
IPR017946 (PLC-like_Pdiesterase_TIM-brl.)
IPR018029 (C2_membr_targeting.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF00168 (C2)
PF00387 (PI-PLC-Y)
PF00388 (PI-PLC-X)
PF09279 (efhand_like)

Target Cross References - Structure

PDBe 2W2W 2W2X
CREDO 2W2W 2W2X
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