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Target Report Card

Target Name and Classification

Target ID CHEMBL4096
Target Type SINGLE PROTEIN
Preferred Name Cellular tumor antigen p53
Synonyms Antigen NY-CO-13 | Cellular tumor antigen p53 | P53 | Phosphoprotein p53 | TP53 | Tumor suppressor p53
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Cellular tumor antigen p53 SINGLE PROTEIN P04637

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907611 Tumour suppressor p53/oncoprotein Mdm2 PROTEIN-PROTEIN INTERACTION
CHEMBL2221344 Tumour suppressor protein p53/Mdm4 PROTEIN-PROTEIN INTERACTION
CHEMBL3301383 CREB-binding protein/p53 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141510
Ensembl ENSG00000141510
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005657 (replication fork)
GO:0005669 (transcription factor TFIID complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0016363 (nuclear matrix)
GO:0016604 (nuclear body)
GO:0016605 (PML body)
GO:0043234 (protein complex)
GO Molecular Function GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001046 (core promoter sequence-specific DNA binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0002020 (protease binding)
GO:0002039 (p53 binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003684 (damaged DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0030971 (receptor tyrosine kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0035035 (histone acetyltransferase binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO:0043621 (protein self-association)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0047485 (protein N-terminus binding)
GO:0051087 (chaperone binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000733 (DNA strand renaturation)
GO:0006284 (base-excision repair)
GO:0006289 (nucleotide-excision repair)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006461 (protein complex assembly)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0006978 (DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)
GO:0006983 (ER overload response)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007265 (Ras protein signal transduction)
GO:0007275 (multicellular organism development)
GO:0007569 (cell aging)
GO:0008104 (protein localization)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008340 (determination of adult lifespan)
GO:0010165 (response to X-ray)
GO:0010332 (response to gamma radiation)
GO:0010628 (positive regulation of gene expression)
GO:0012501 (programmed cell death)
GO:0016032 (viral process)
GO:0016925 (protein sumoylation)
GO:0030154 (cell differentiation)
GO:0030308 (negative regulation of cell growth)
GO:0030330 (DNA damage response, signal transduction by p53 class mediator)
GO:0031065 (positive regulation of histone deacetylation)
GO:0031497 (chromatin assembly)
GO:0031571 (mitotic G1 DNA damage checkpoint)
GO:0032461 (positive regulation of protein oligomerization)
GO:0034613 (cellular protein localization)
GO:0034644 (cellular response to UV)
GO:0035690 (cellular response to drug)
GO:0042149 (cellular response to glucose starvation)
GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043153 (entrainment of circadian clock by photoperiod)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046677 (response to antibiotic)
GO:0046827 (positive regulation of protein export from nucleus)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0048511 (rhythmic process)
GO:0048512 (circadian behavior)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0051097 (negative regulation of helicase activity)
GO:0051262 (protein tetramerization)
GO:0051974 (negative regulation of telomerase activity)
GO:0070245 (positive regulation of thymocyte apoptotic process)
GO:0071158 (positive regulation of cell cycle arrest)
GO:0071456 (cellular response to hypoxia)
GO:0071479 (cellular response to ionizing radiation)
GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0090399 (replicative senescence)
GO:0090403 (oxidative stress-induced premature senescence)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:0097252 (oligodendrocyte apoptotic process)
GO:1900119 (positive regulation of execution phase of apoptosis)
GO:1900740 (positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1902749 (regulation of cell cycle G2/M phase transition)
GO:1990440 (positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)
Wikipedia P53

Target Cross References - Protein

canSAR P04637
CGD Li-Fraumeni syndrome; Choroid plexus papilloma; Ependymoma, intracranial; Osteogenic sarcoma; Breast cancer, familial; Hepatoblastoma; Non-Hodgkin lymphoma; Adrenocortical carcinoma; Colorectal cancer
Human Protein Atlas ENSG00000141510
IntAct P04637
Open Targets ENSG00000141510
PharmGKB PA36679
Reactome R-HSA-111448 (Activation of NOXA and translocation to mitochondria.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-139915 (Activation of PUMA and translocation to mitochondria.)
R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2559584 (Formation of Senescence-Associated Heterochromatin Foci (SAHF).)
R-HSA-2559585 (Oncogene Induced Senescence.)
R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
R-HSA-3232118 (SUMOylation of transcription factors.)
R-HSA-349425 (Autodegradation of the E3 ubiquitin ligase COP1.)
R-HSA-390471 (Association of TriC/CCT with target proteins during biosynthesis.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-5689896 (Ovarian tumor domain proteases.)
R-HSA-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6803204 (TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.)
R-HSA-6803205 (TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.)
R-HSA-6803207 (TP53 Regulates Transcription of Caspase Activators and Caspases.)
R-HSA-6803211 (TP53 Regulates Transcription of Death Receptors and Ligands.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-HSA-6804115 (TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.)
R-HSA-6804116 (TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.)
R-HSA-6804754 (Regulation of TP53 Expression.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-6804759 (Regulation of TP53 Activity through Association with Co-factors.)
R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
R-HSA-6811555 (PI5P Regulates TP53 Acetylation.)
R-HSA-69473 (G2/M DNA damage checkpoint.)
R-HSA-69481 (G2/M Checkpoints.)
R-HSA-69541 (Stabilization of p53.)
R-HSA-69895 (Transcriptional activation of cell cycle inhibitor p21.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt P04637 Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848 Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2 Q9NZD0 Q9UBI2 Q9UQ61

Target Cross References - Domain

InterPro IPR002117 (p53_tumour_suppressor.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR010991 (p53_tetrameristn.)
IPR011615 (p53_DNA-bd.)
IPR012346 (p53/RUNT-type_TF_DNA-bd.)
IPR013872 (p53_transactivation_domain.)
Pfam PF00870 (P53)
PF07710 (P53_tetramer)
PF08563 (P53_TAD)

Target Cross References - Structure

PDBe 1AIE 1C26 1GZH 1H26 1KZY 1MA3 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ More...
CREDO 1AIE 1C26 1GZH 1H26 1KZY 1MA3 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ More...
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