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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4093
Target Type SINGLE PROTEIN
Preferred Name LXR-beta
Synonyms LXRB | Liver X receptor beta | NER | NR1H2 | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | UNR | Ubiquitously-expressed nuclear receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group h > nuclear hormone receptor subfamily 1 group h member 3

Target Components

Component Description Relationship Accession
Oxysterols receptor LXR-beta SINGLE PROTEIN P55055

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000131408
Ensembl ENSG00000131408
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003707 (steroid hormone receptor activity)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0010867 (positive regulation of triglyceride biosynthetic process)
GO:0010875 (positive regulation of cholesterol efflux)
GO:0010887 (negative regulation of cholesterol storage)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032369 (negative regulation of lipid transport)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0045723 (positive regulation of fatty acid biosynthetic process)
GO:0045892 (negative regulation of transcription, DNA-dependent)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048550 (negative regulation of pinocytosis)
GO:0051006 (positive regulation of lipoprotein lipase activity)
GO:0060336 (negative regulation of interferon-gamma-mediated signaling pathway)
Wikipedia Liver_X_receptor_beta

Target Cross References - Protein

Human Protein Atlas ENSG00000131408
IntAct P55055
Guide to Pharmacology 601 (Liver X receptor-Beta;)
PharmGKB PA31750
Reactome REACT_71 (Gene Expression.)
UniProt A8K490 P55055 Q12970 Q5I0Y1

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
IPR023257 (Liver_X_rcpt.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E
CREDO 1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E
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