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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4081
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor III
Synonyms CD_antigen=CD142 | Coagulation factor III | F3 | TF | Thromboplastin | Tissue factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor
  • surface antigen

Target Components

Component Description Relationship Accession
Tissue factor SINGLE PROTEIN P13726

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095194 Coagulation factor VII/tissue factor PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117525
Ensembl ENSG00000117525
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031012 (extracellular matrix)
GO:0031233 (intrinsic component of external side of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0002020 (protease binding)
GO:0004896 (cytokine receptor activity)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO Biological Process GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
GO:0002543 (activation of blood coagulation via clotting cascade)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007568 (aging)
GO:0007596 (blood coagulation)
GO:0007598 (blood coagulation, extrinsic pathway)
GO:0007599 (hemostasis)
GO:0009266 (response to temperature stimulus)
GO:0009611 (response to wounding)
GO:0009612 (response to mechanical stimulus)
GO:0010641 (positive regulation of platelet-derived growth factor receptor signaling pathway)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030335 (positive regulation of cell migration)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0034405 (response to fluid shear stress)
GO:0045766 (positive regulation of angiogenesis)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055098 (response to low-density lipoprotein particle)
GO:0070301 (cellular response to hydrogen peroxide)
Wikipedia Tissue_factor

Target Cross References - Protein

canSAR P13726
Human Protein Atlas ENSG00000117525
IntAct P13726
Open Targets ENSG00000117525
PharmGKB PA158
Reactome R-HSA-140834 (Extrinsic Pathway of Fibrin Clot Formation.)
UniProt D3DT47 P13726 Q6FHG2 Q86WH4

Target Cross References - Domain

InterPro IPR001187 (Tissue_factor.)
IPR003961 (FN3_dom.)
IPR013783 (Ig-like_fold.)
IPR015373 (Interferon/interleukin_rcp_dom.)
IPR016354 (Tissue_fac/coagulation_fac-3.)
IPR030472 (Tissue_Factor_CS.)
Pfam PF01108 (Tissue_fac)
PF09294 (Interfer-bind)

Target Cross References - Structure

PDBe 1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2EC9 More...
CREDO 1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2EC9 More...
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