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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4073
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase 7
Synonyms MMP-7 | MMP7 | MPSL1 | Matrilysin | Matrin | Matrix metalloproteinase-7 | PUMP1 | Pump-1 protease | Uterine metalloproteinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Matrilysin SINGLE PROTEIN P09237

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200567 DOXYCYCLINE HYCLATE Matrix metalloproteinase 7 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL1200699 DOXYCYCLINE HYDRATE Matrix metalloproteinase 7 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL2364574 DOXYCYCLINE CALCIUM Matrix metalloproteinase 7 inhibitor 4 DailyMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137673
Ensembl ENSG00000137673
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0009986 (cell surface)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0008201 (heparin binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007568 (aging)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0031667 (response to nutrient levels)
GO:0044849 (estrous cycle)
GO:0060135 (maternal process involved in female pregnancy)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia MMP7

Target Cross References - Protein

canSAR P09237
Human Protein Atlas ENSG00000137673
IntAct P09237
Guide to Pharmacology 1631
Open Targets ENSG00000137673
PharmGKB PA30887
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
UniProt P09237 Q9BTK9

Target Cross References - Domain

InterPro IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR028707 (Matrilysin.)
IPR033739 (M10A_MMP.)
Pfam PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1MMP 1MMQ 1MMR 2Y6C 2Y6D
CREDO 1MMP 1MMQ 1MMR 2Y6C 2Y6D
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