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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4071
Target Type SINGLE PROTEIN
Preferred Name Cathepsin G
Synonyms CG | CTSG | Cathepsin G
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Cathepsin G SINGLE PROTEIN P08311

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100448
Ensembl ENSG00000100448
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0030141 (secretory granule)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0002003 (angiotensin maturation)
GO:0006468 (protein phosphorylation)
GO:0006508 (proteolysis)
GO:0006955 (immune response)
GO:0016485 (protein processing)
GO:0022617 (extracellular matrix disassembly)
GO:0032496 (response to lipopolysaccharide)
GO:0042742 (defense response to bacterium)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0044267 (cellular protein metabolic process)
GO:0050778 (positive regulation of immune response)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050832 (defense response to fungus)
GO:0070946 (neutrophil mediated killing of gram-positive bacterium)
Wikipedia Cathepsin_G

Target Cross References - Protein

canSAR P08311
Human Protein Atlas ENSG00000100448
IntAct P08311
Guide to Pharmacology 2348
Open Targets ENSG00000100448
PharmGKB PA27032
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6803157 (Antimicrobial peptides.)
UniProt P08311 Q6IBJ6 Q9UCA5 Q9UCU6

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1AU8 1CGH 1KYN 1T32
CREDO 1AU8 1CGH 1KYN 1T32
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