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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4068
Target Type SINGLE PROTEIN
Preferred Name Chymase
Synonyms Alpha-chymase | CMA1 | CYH | CYM | Chymase | Mast cell protease I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Chymase SINGLE PROTEIN P23946

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000092009
Ensembl ENSG00000092009
GO Cellular Component GO:0005576 (extracellular region)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0050720 (interleukin-1 beta biosynthetic process)
Wikipedia CMA1

Target Cross References - Protein

canSAR P23946
Human Protein Atlas ENSG00000092009
Guide to Pharmacology 2340 (chymase 1, mast cell)
PharmGKB PA26623
UniProt B5BUM8 P23946 Q16018 Q3SY36 Q9UDH5

Target Cross References - Domain

InterPro IPR001254 (Peptidase_S1_S6.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Pept_cys/ser_Trypsin-like.)
IPR018114 (Peptidase_S1/S6_AS.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1KLT 1NN6 1PJP 1T31 2HVX 3N7O
CREDO 1KLT 1NN6 1PJP 1T31 2HVX 3N7O
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