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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4068
Target Type SINGLE PROTEIN
Preferred Name Chymase
Synonyms Alpha-chymase | CMA1 | CYH | CYM | Chymase | Mast cell protease I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Chymase SINGLE PROTEIN P23946

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000092009
Ensembl ENSG00000092009
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0031012 (extracellular matrix)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0002003 (angiotensin maturation)
GO:0006508 (proteolysis)
GO:0006518 (peptide metabolic process)
GO:0006955 (immune response)
GO:0016485 (protein processing)
GO:0022617 (extracellular matrix disassembly)
GO:0030901 (midbrain development)
GO:0045766 (positive regulation of angiogenesis)
GO:0050720 (interleukin-1 beta biosynthetic process)
GO:0050727 (regulation of inflammatory response)
GO:0071333 (cellular response to glucose stimulus)
Wikipedia CMA1

Target Cross References - Protein

canSAR P23946
Human Protein Atlas ENSG00000092009
Guide to Pharmacology 2340
Open Targets ENSG00000092009
PharmGKB PA26623
Reactome R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt B5BUM8 P23946 Q16018 Q3SY36 Q3SY37 Q9UDH5

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0
CREDO 1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0
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