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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL4055
Target Type SINGLE PROTEIN
Preferred Name Gamma-glutamylcysteine synthetase
Synonyms GCLC | GCS heavy chain | GLCL | GLCLC | Gamma-ECS | Gamma-glutamylcysteine synthetase | Glutamate--cysteine ligase catalytic subunit
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutamate--cysteine ligase catalytic subunit SINGLE PROTEIN P48506

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000001084
Ensembl ENSG00000001084
GO Cellular Component GO:0005829 (cytosol)
GO:0017109 (glutamate-cysteine ligase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004357 (glutamate-cysteine ligase activity)
GO:0005524 (ATP binding)
GO:0016595 (glutamate binding)
GO:0016874 (ligase activity)
GO:0043531 (ADP binding)
GO:0046982 (protein heterodimerization activity)
GO:0050662 (coenzyme binding)
GO Biological Process GO:0000096 (sulfur amino acid metabolic process)
GO:0006534 (cysteine metabolic process)
GO:0006536 (glutamate metabolic process)
GO:0006749 (glutathione metabolic process)
GO:0006750 (glutathione biosynthetic process)
GO:0006979 (response to oxidative stress)
GO:0008637 (apoptotic mitochondrial changes)
GO:0009408 (response to heat)
GO:0009410 (response to xenobiotic stimulus)
GO:0009725 (response to hormone)
GO:0019852 (L-ascorbic acid metabolic process)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045454 (cell redox homeostasis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0046685 (response to arsenic-containing substance)
GO:0050880 (regulation of blood vessel size)
GO:0051409 (response to nitrosative stress)
GO:0051900 (regulation of mitochondrial depolarization)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia GCLC

Target Cross References - Protein

canSAR P48506
CGD Gamma-glutamylcysteine synthetase deficiency
Human Protein Atlas ENSG00000001084
IntAct P48506
Open Targets ENSG00000001084
PharmGKB PA28612
Reactome R-HSA-1614635 (Sulfur amino acid metabolism.)
R-HSA-174403 (Glutathione synthesis and recycling.)
UniProt P48506 Q14399

Target Cross References - Domain

InterPro IPR004308 (GCS.)
Pfam PF03074 (GCS)
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