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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4050
Target Type SINGLE PROTEIN
Preferred Name FK506 binding protein 4
Synonyms 51 kDa FK506-binding protein | 52 kDa FK506-binding protein | 52 kDa FKBP | 59 kDa immunophilin | FK506-binding protein 4 | FKBP-4 | FKBP-52 | FKBP4 | FKBP51 | FKBP52 | FKBP59 | HBI | HSP-binding immunophilin | Immunophilin FKBP52 | PPIase FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed | Rotamase | p59
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Peptidyl-prolyl cis-trans isomerase FKBP4 SINGLE PROTEIN Q02790

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000004478
Ensembl ENSG00000004478
GO Cellular Component GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO:0005874 (microtubule)
GO:0016020 (membrane)
GO:0044295 (axonal growth cone)
GO Molecular Function GO:0003755 (peptidyl-prolyl cis-trans isomerase activity)
GO:0005528 (FK506 binding)
GO:0030674 (protein binding, bridging)
GO:0031072 (heat shock protein binding)
GO Biological Process GO:0006457 (protein folding)
GO:0010977 (negative regulation of neuron projection development)
GO:0031111 (negative regulation of microtubule polymerization or depolymerization)
Wikipedia FKBP52

Target Cross References - Protein

canSAR Q02790
Human Protein Atlas ENSG00000004478
IntAct Q02790
PharmGKB PA28161
UniProt D3DUQ1 Q02790 Q9UCP1 Q9UCV7

Target Cross References - Domain

InterPro IPR001179 (PPIase_FKBP_dom.)
IPR001440 (TPR-1.)
IPR011990 (TPR-like_helical.)
IPR013026 (TPR-contain.)
IPR019734 (TPR_repeat.)
IPR023114 (Elongated_TPR_rpt_dom.)
IPR023566 (PPIase_FKBP.)
Pfam PF00254 (FKBP_C)
PF00515 (TPR_1)

Target Cross References - Structure

PDBe 1N1A 1P5Q 1Q1C 1QZ2
CREDO 1N1A 1P5Q 1Q1C 1QZ2
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