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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4050
Target Type SINGLE PROTEIN
Preferred Name FK506 binding protein 4
Synonyms 51 kDa FK506-binding protein | 52 kDa FK506-binding protein | 52 kDa FKBP | 59 kDa immunophilin | FK506-binding protein 4 | FKBP-4 | FKBP-52 | FKBP4 | FKBP51 | FKBP52 | FKBP59 | HBI | HSP-binding immunophilin | Immunophilin FKBP52 | PPIase FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed | Rotamase | p59
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Peptidyl-prolyl cis-trans isomerase FKBP4 SINGLE PROTEIN Q02790

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000004478
Ensembl ENSG00000004478
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0030424 (axon)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043234 (protein complex)
GO:0044295 (axonal growth cone)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003755 (peptidyl-prolyl cis-trans isomerase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005525 (GTP binding)
GO:0005528 (FK506 binding)
GO:0016853 (isomerase activity)
GO:0030674 (protein binding, bridging)
GO:0031072 (heat shock protein binding)
GO:0032767 (copper-dependent protein binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0044822 (poly(A) RNA binding)
GO:0048156 (tau protein binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0000413 (protein peptidyl-prolyl isomerization)
GO:0006457 (protein folding)
GO:0006463 (steroid hormone receptor complex assembly)
GO:0006825 (copper ion transport)
GO:0007566 (embryo implantation)
GO:0010977 (negative regulation of neuron projection development)
GO:0030521 (androgen receptor signaling pathway)
GO:0030850 (prostate gland development)
GO:0031111 (negative regulation of microtubule polymerization or depolymerization)
GO:0031115 (negative regulation of microtubule polymerization)
GO:0031503 (protein complex localization)
GO:0046661 (male sex differentiation)
GO:0048608 (reproductive structure development)
GO:0061077 (chaperone-mediated protein folding)
GO:1900034 (regulation of cellular response to heat)
Wikipedia FKBP52

Target Cross References - Protein

canSAR Q02790
Human Protein Atlas ENSG00000004478
IntAct Q02790
Open Targets ENSG00000004478
PharmGKB PA28161
Reactome R-HSA-3371568 (Attenuation phase.)
UniProt D3DUQ1 Q02790 Q9UCP1 Q9UCV7

Target Cross References - Domain

InterPro IPR001179 (PPIase_FKBP_dom.)
IPR001440 (TPR_1.)
IPR011990 (TPR-like_helical_dom.)
IPR013026 (TPR-contain_dom.)
IPR013105 (TPR_2.)
IPR019734 (TPR_repeat.)
IPR023566 (PPIase_FKBP.)
IPR031212 (FKBP4.)
Pfam PF00254 (FKBP_C)
PF00515 (TPR_1)
PF07719 (TPR_2)

Target Cross References - Structure

PDBe 1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8
CREDO 1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8
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