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Target Report Card

Target Name and Classification

Target ID CHEMBL4046
Preferred Name Inositol 1,4,5-trisphosphate receptor type 1
Synonyms INSP3R1 | IP3 receptor isoform 1 | IP3R 1 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | InsP3R1 | Type 1 InsP3 receptor | Type 1 inositol 1,4,5-trisphosphate receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ip3 receptor

Target Components

Component Description Relationship Accession
Inositol 1,4,5-trisphosphate receptor type 1 SINGLE PROTEIN Q14643

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111451 Inositol 1,4,5-trisphosphate receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000150995
Ensembl ENSG00000150995
GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005637 (nuclear inner membrane)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005955 (calcineurin complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030658 (transport vesicle membrane)
GO:0031088 (platelet dense granule membrane)
GO:0031094 (platelet dense tubular network)
GO:0031095 (platelet dense tubular network membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0032991 (macromolecular complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005220 (inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)
GO:0005262 (calcium channel activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0015085 (calcium ion transmembrane transporter activity)
GO:0015278 (calcium-release channel activity)
GO:0019855 (calcium channel inhibitor activity)
GO:0035091 (phosphatidylinositol binding)
GO:0070679 (inositol 1,4,5 trisphosphate binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0009791 (post-embryonic development)
GO:0010506 (regulation of autophagy)
GO:0030168 (platelet activation)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0042045 (epithelial fluid transport)
GO:0048016 (inositol phosphate-mediated signaling)
GO:0050796 (regulation of insulin secretion)
GO:0050849 (negative regulation of calcium-mediated signaling)
GO:0050882 (voluntary musculoskeletal movement)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0055085 (transmembrane transport)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0070588 (calcium ion transmembrane transport)
GO:1903779 (regulation of cardiac conduction)
Wikipedia ITPR1

Target Cross References - Protein

canSAR Q14643
CGD Spinocerebellar ataxia 15
Human Protein Atlas ENSG00000150995
IntAct Q14643
Guide to Pharmacology 743
Open Targets ENSG00000150995
PharmGKB PA29978
Pharos Q14643 (Tchem)
Reactome R-HSA-112043 (PLC beta mediated events.)
R-HSA-114508 (Effects of PIP2 hydrolysis.)
R-HSA-139853 (Elevation of cytosolic Ca2+ levels.)
R-HSA-1489509 (DAG and IP3 signaling.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-418457 (cGMP effects.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5607763 (CLEC7A (Dectin-1) induces NFAT activation.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt E7EPX7 E9PDE9 Q14643 Q14660 Q99897

Target Cross References - Domain

InterPro IPR000493 (InsP3_rcpt.)
IPR000699 (RIH_dom.)
IPR005821 (Ion_trans_dom.)
IPR013662 (RIH_assoc-dom.)
IPR014821 (Ins145_P3_rcpt.)
IPR015925 (Ryanodine_recept-rel.)
IPR016024 (ARM-type_fold.)
IPR016093 (MIR_motif.)
IPR035910 (RyR/IP3R_RIH_dom_sf.)
IPR036300 (MIR_dom_sf.)
Pfam PF00520 (Ion_trans)
PF02815 (MIR)
PF08454 (RIH_assoc)
PF08709 (Ins145_P3_rec)