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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4045
Target Type SINGLE PROTEIN
Preferred Name AMP-activated protein kinase, alpha-1 subunit
Synonyms 5'-AMP-activated protein kinase catalytic subunit alpha-1 | ACACA kinase | AMPK subunit alpha-1 | AMPK1 | Acetyl-CoA carboxylase kinase | HMGCR kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase ampk subfamily

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase catalytic subunit alpha-1 SINGLE PROTEIN Q13131

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038453 AMPK alpha1/beta2/gamma1 PROTEIN COMPLEX
CHEMBL3038452 AMPK alpha1/beta1/gamma3 PROTEIN COMPLEX
CHEMBL3038451 AMPK alpha1/beta1/gamma2 PROTEIN COMPLEX
CHEMBL2111345 AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 PROTEIN COMPLEX
CHEMBL3038454 AMPK alpha1/alpha2 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132356
Ensembl ENSG00000132356
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001666 (response to hypoxia)
GO:0006633 (fatty acid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0007050 (cell cycle arrest)
GO:0008286 (insulin receptor signaling pathway)
GO:0045542 (positive regulation of cholesterol biosynthetic process)
GO:0045768 (positive regulation of anti-apoptosis)
GO:0046318 (negative regulation of glucosylceramide biosynthetic process)
GO:0046320 (regulation of fatty acid oxidation)
Wikipedia Protein_kinase,_AMP-activated,_alpha_1

Target Cross References - Protein

canSAR Q13131
Human Protein Atlas ENSG00000132356
IntAct Q13131
PharmGKB PA33744
Reactome REACT_11163 (Activated AMPK stimulates fatty-acid oxidation in muscle.)
REACT_498 (Signaling by Insulin receptor.)
UniProt A8MTQ6 B2R7E1 O00286 Q13131 Q5D0E1 Q86VS1 Q9UNQ4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
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