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Target Report Card

Target Name and Classification

Target ID CHEMBL4029
Preferred Name Interleukin-8 receptor A
Synonyms C-X-C chemokine receptor type 1 | CD_antigen=CD181 | CDw128a | CMKAR1 | CXC-R1 | CXCR-1 | CXCR1 | High affinity interleukin-8 receptor A | IL-8 receptor type 1 | IL-8R A | IL8RA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cxc chemokine receptor

Target Components

Component Description Relationship Accession
C-X-C chemokine receptor type 1 SINGLE PROTEIN P25024

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096909 Interleukin-8 receptors, CXCR1/CXCR2 PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL191413 REPARIXIN Interleukin-8 receptor A modulator 3 PubMed PubMed
CHEMBL189475 Ladarixin Interleukin-8 receptor A modulator 2 PubMed
CHEMBL2103864 NAVARIXIN HYDRATE Interleukin-8 receptor A antagonist 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163464
Ensembl ENSG00000163464
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004918 (interleukin-8 receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0016494 (C-X-C chemokine receptor activity)
GO:0019959 (interleukin-8 binding)
GO Biological Process GO:0002407 (dendritic cell chemotaxis)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0031623 (receptor internalization)
GO:0038112 (interleukin-8-mediated signaling pathway)
GO:0070098 (chemokine-mediated signaling pathway)
Wikipedia Interleukin_8_receptor,_alpha

Target Cross References - Protein

canSAR P25024
Human Protein Atlas ENSG00000163464
IntAct P25024
Guide to Pharmacology 68
Open Targets ENSG00000163464
PharmGKB PA29842
Pharos P25024 (Tchem)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B2R6Q3 P25024 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2

Target Cross References - Domain

InterPro IPR000174 (Chemokine_CXCR_1/2.)
IPR000276 (GPCR_Rhodpsn.)
IPR001355 (Chemokine_CXCR1.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)