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Target Report Card

Target Name and Classification

Target ID CHEMBL4026
Preferred Name Signal transducer and activator of transcription 3
Synonyms APRF | Acute-phase response factor | STAT3 | Signal transducer and activator of transcription 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Signal transducer and activator of transcription 3 SINGLE PROTEIN P40763

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168610
Ensembl ENSG00000168610
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004871 (signal transducer activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0031490 (chromatin DNA binding)
GO:0031730 (CCR5 chemokine receptor binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001659 (temperature homeostasis)
GO:0001754 (eye photoreceptor cell differentiation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006606 (protein import into nucleus)
GO:0006928 (movement of cell or subcellular component)
GO:0006953 (acute-phase response)
GO:0007165 (signal transduction)
GO:0007259 (JAK-STAT cascade)
GO:0007399 (nervous system development)
GO:0007568 (aging)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010033 (response to organic substance)
GO:0010628 (positive regulation of gene expression)
GO:0010730 (negative regulation of hydrogen peroxide biosynthetic process)
GO:0014070 (response to organic cyclic compound)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019827 (stem cell population maintenance)
GO:0019953 (sexual reproduction)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032355 (response to estradiol)
GO:0032870 (cellular response to hormone stimulus)
GO:0033210 (leptin-mediated signaling pathway)
GO:0034097 (response to cytokine)
GO:0035019 (somatic stem cell population maintenance)
GO:0035278 (miRNA mediated inhibition of translation)
GO:0040014 (regulation of multicellular organism growth)
GO:0042493 (response to drug)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0042593 (glucose homeostasis)
GO:0042755 (eating behavior)
GO:0043066 (negative regulation of apoptotic process)
GO:0043434 (response to peptide hormone)
GO:0044320 (cellular response to leptin stimulus)
GO:0044321 (response to leptin)
GO:0045471 (response to ethanol)
GO:0045747 (positive regulation of Notch signaling pathway)
GO:0045820 (negative regulation of glycolytic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0048708 (astrocyte differentiation)
GO:0051726 (regulation of cell cycle)
GO:0060019 (radial glial cell differentiation)
GO:0060259 (regulation of feeding behavior)
GO:0060396 (growth hormone receptor signaling pathway)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0060548 (negative regulation of cell death)
GO:0070102 (interleukin-6-mediated signaling pathway)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0097009 (energy homeostasis)
GO:1901215 (negative regulation of neuron death)
GO:1902728 (positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1904685 (positive regulation of metalloendopeptidase activity)
GO:2000637 (positive regulation of gene silencing by miRNA)
GO:2001171 (positive regulation of ATP biosynthetic process)
GO:2001223 (negative regulation of neuron migration)
Wikipedia STAT3

Target Cross References - Protein

canSAR P40763
CGD Hyper-IgE recurrent infection syndrome
Human Protein Atlas ENSG00000168610
IntAct P40763
Open Targets ENSG00000168610
PharmGKB PA337
Reactome R-HSA-1059683 (Interleukin-6 signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1839117 (Signaling by cytosolic FGFR1 fusion mutants.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-198745 (Signalling to STAT3.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2586552 (Signaling by Leptin.)
R-HSA-2892247 (POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.)
R-HSA-390471 (Association of TriC/CCT with target proteins during biosynthesis.)
R-HSA-452723 (Transcriptional regulation of pluripotent stem cells.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-8849474 (PTK6 Activates STAT3.)
R-HSA-8875791 (MET activates STAT3.)
R-HSA-982772 (Growth hormone receptor signaling.)
UniProt A8K7B8 K7ENL3 O14916 P40763 Q9BW54

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011992 (EF-hand-dom_pair.)
IPR012345 (STAT_TF_DNA-bd_sub.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)

Target Cross References - Structure