ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4026
Target Type SINGLE PROTEIN
Preferred Name Signal transducer and activator of transcription 3
Synonyms APRF | Acute-phase response factor | STAT3 | Signal transducer and activator of transcription 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Signal transducer and activator of transcription 3 SINGLE PROTEIN P40763

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168610
Ensembl ENSG00000168610
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004871 (signal transducer activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0031490 (chromatin DNA binding)
GO:0031730 (CCR5 chemokine receptor binding)
GO:0035259 (glucocorticoid receptor binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001659 (temperature homeostasis)
GO:0001754 (eye photoreceptor cell differentiation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006606 (protein import into nucleus)
GO:0006928 (movement of cell or subcellular component)
GO:0006953 (acute-phase response)
GO:0007165 (signal transduction)
GO:0007259 (JAK-STAT cascade)
GO:0007399 (nervous system development)
GO:0007568 (aging)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010033 (response to organic substance)
GO:0010628 (positive regulation of gene expression)
GO:0010730 (negative regulation of hydrogen peroxide biosynthetic process)
GO:0014070 (response to organic cyclic compound)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019827 (stem cell population maintenance)
GO:0019953 (sexual reproduction)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032355 (response to estradiol)
GO:0032870 (cellular response to hormone stimulus)
GO:0033210 (leptin-mediated signaling pathway)
GO:0034097 (response to cytokine)
GO:0035019 (somatic stem cell population maintenance)
GO:0035278 (miRNA mediated inhibition of translation)
GO:0040014 (regulation of multicellular organism growth)
GO:0042493 (response to drug)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0042593 (glucose homeostasis)
GO:0042755 (eating behavior)
GO:0043066 (negative regulation of apoptotic process)
GO:0043434 (response to peptide hormone)
GO:0044320 (cellular response to leptin stimulus)
GO:0044321 (response to leptin)
GO:0045471 (response to ethanol)
GO:0045747 (positive regulation of Notch signaling pathway)
GO:0045820 (negative regulation of glycolytic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046902 (regulation of mitochondrial membrane permeability)
GO:0048708 (astrocyte differentiation)
GO:0051726 (regulation of cell cycle)
GO:0060019 (radial glial cell differentiation)
GO:0060259 (regulation of feeding behavior)
GO:0060396 (growth hormone receptor signaling pathway)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0060548 (negative regulation of cell death)
GO:0070102 (interleukin-6-mediated signaling pathway)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0097009 (energy homeostasis)
GO:1901215 (negative regulation of neuron death)
GO:1902728 (positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1904685 (positive regulation of metalloendopeptidase activity)
GO:2000637 (positive regulation of gene silencing by miRNA)
GO:2001171 (positive regulation of ATP biosynthetic process)
GO:2001223 (negative regulation of neuron migration)
Wikipedia STAT3

Target Cross References - Protein

canSAR P40763
CGD Hyper-IgE recurrent infection syndrome
Human Protein Atlas ENSG00000168610
IntAct P40763
Open Targets ENSG00000168610
PharmGKB PA337
Reactome R-HSA-1059683 (Interleukin-6 signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1839117 (Signaling by cytosolic FGFR1 fusion mutants.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-198745 (Signalling to STAT3.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2586552 (Signaling by Leptin.)
R-HSA-2892247 (POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.)
R-HSA-390471 (Association of TriC/CCT with target proteins during biosynthesis.)
R-HSA-452723 (Transcriptional regulation of pluripotent stem cells.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-8849474 (PTK6 Activates STAT3.)
R-HSA-8875791 (MET activates STAT3.)
R-HSA-982772 (Growth hormone receptor signaling.)
TIMBAL STAT3
UniProt A8K7B8 K7ENL3 O14916 P40763 Q9BW54

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011992 (EF-hand-dom_pair.)
IPR012345 (STAT_TF_DNA-bd_sub.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)

Target Cross References - Structure

PDBe 5AX3
CREDO 5AX3
spacer
spacer