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Target Report Card

Target Name and Classification

Target ID CHEMBL4026
Preferred Name Signal transducer and activator of transcription 3
Synonyms APRF | Acute-phase response factor | STAT3 | Signal transducer and activator of transcription 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Signal transducer and activator of transcription 3 SINGLE PROTEIN P40763

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168610
Ensembl ENSG00000168610
GO Cellular Component GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003706 (ligand-regulated transcription factor activity)
GO:0004871 (signal transducer activity)
GO:0005509 (calcium ion binding)
GO:0008134 (transcription factor binding)
GO:0010843 (promoter binding)
GO:0016563 (transcription activator activity)
GO:0019901 (protein kinase binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001659 (temperature homeostasis)
GO:0001754 (eye photoreceptor cell differentiation)
GO:0006606 (protein import into nucleus)
GO:0006928 (cellular component movement)
GO:0019953 (sexual reproduction)
GO:0032355 (response to estradiol stimulus)
GO:0042593 (glucose homeostasis)
GO:0042755 (eating behavior)
GO:0044419 (interspecies interaction between organisms)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0070102 (interleukin-6-mediated signaling pathway)
Wikipedia STAT3

Target Cross References - Protein

canSAR P40763
CGD Hyper-IgE recurrent infection syndrome
Human Protein Atlas ENSG00000168610
IntAct P40763
PharmGKB PA337
Reactome REACT_11061 (Signalling by NGF.)
REACT_16888 (Signaling by PDGF.)
REACT_6900 (Signaling in Immune system.)
UniProt O14916 P40763 Q9BW54

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001217 (STAT_TF_core.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011992 (EF-hand-like_dom.)
IPR012345 (STAT_TF_DNA-bd_sub.)
IPR013799 (STAT_TF_prot_interaction.)
IPR013800 (STAT_TF_alpha.)
IPR013801 (STAT_TF_DNA-bd.)
IPR015988 (STAT_TF_coiled-coil.)
Pfam PF00017 (SH2)
PF01017 (STAT_alpha)
PF02864 (STAT_bind)
PF02865 (STAT_int)