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Target Report Card

Target Name and Classification

Target ID CHEMBL4015
Target Type SINGLE PROTEIN
Preferred Name C-C chemokine receptor type 2
Synonyms C-C CKR-2 | C-C chemokine receptor type 2 | CC-CKR-2 | CCR-2 | CCR2 | CCR2 | CD_antigen=CD192 | CMKBR2 | MCP-1-R | Monocyte chemoattractant protein 1 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 2 SINGLE PROTEIN P41597

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2110727 CENICRIVIROC C-C chemokine receptor type 2 antagonist 3 PubMed PubMed PubMed
CHEMBL2109339 MLN-1202 C-C chemokine receptor type 2 antagonist 2 Other PubMed
CHEMBL3545032 PF-04634817 C-C chemokine receptor type 2 antagonist 2 Other
CHEMBL3545221 AZD2423 C-C chemokine receptor type 2 antagonist 2 PubMed
CHEMBL3545286 CCX140 C-C chemokine receptor type 2 antagonist 2 PubMed
CHEMBL3707228 PLOZALIZUMAB C-C chemokine receptor type 2 inhibitor 0 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121807
Ensembl ENSG00000121807
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0005515 (protein binding)
GO:0016493 (C-C chemokine receptor activity)
GO:0019955 (cytokine binding)
GO:0031727 (CCR2 chemokine receptor binding)
GO:0035715 (chemokine (C-C motif) ligand 2 binding)
GO:0035716 (chemokine (C-C motif) ligand 12 binding)
GO:0035717 (chemokine (C-C motif) ligand 7 binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001974 (blood vessel remodeling)
GO:0002407 (dendritic cell chemotaxis)
GO:0002548 (monocyte chemotaxis)
GO:0002827 (positive regulation of T-helper 1 type immune response)
GO:0002829 (negative regulation of type 2 immune response)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006959 (humoral immune response)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007259 (JAK-STAT cascade)
GO:0009611 (response to wounding)
GO:0010574 (regulation of vascular endothelial growth factor production)
GO:0010820 (positive regulation of T cell chemotaxis)
GO:0016032 (viral process)
GO:0016525 (negative regulation of angiogenesis)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019233 (sensory perception of pain)
GO:0019725 (cellular homeostasis)
GO:0030097 (hemopoiesis)
GO:0030334 (regulation of cell migration)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032743 (positive regulation of interleukin-2 production)
GO:0035705 (T-helper 17 cell chemotaxis)
GO:0042535 (positive regulation of tumor necrosis factor biosynthetic process)
GO:0043310 (negative regulation of eosinophil degranulation)
GO:0046641 (positive regulation of alpha-beta T cell proliferation)
GO:0048873 (homeostasis of number of cells within a tissue)
GO:0050729 (positive regulation of inflammatory response)
GO:0050870 (positive regulation of T cell activation)
GO:0061756 (leukocyte adhesion to vascular endothelial cell)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0090026 (positive regulation of monocyte chemotaxis)
GO:0090265 (positive regulation of immune complex clearance by monocytes and macrophages)
GO:0097350 (neutrophil clearance)
GO:1903238 (positive regulation of leukocyte tethering or rolling)
GO:2000439 (positive regulation of monocyte extravasation)
GO:2000451 (positive regulation of CD8-positive, alpha-beta T cell extravasation)
GO:2000464 (positive regulation of astrocyte chemotaxis)
GO:2000473 (positive regulation of hematopoietic stem cell migration)

Target Cross References - Protein

canSAR P41597
Human Protein Atlas ENSG00000121807
IntAct P41597
Guide to Pharmacology 59
Open Targets ENSG00000121807
PharmGKB PA26167
Pharos P41597 (Tchem)
Reactome R-HSA-1461957 (Beta defensins.)
R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6783783 (Interleukin-10 signaling.)
UniProt A0AVQ3 B2RMT0 O95950 P41597 Q4VBL2

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR002237 (Chemokine_CCR2.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 5T1A
CREDO 5T1A
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