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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4014
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase ABL2
Synonyms ABL2 | ABLL | ARG | Abelson murine leukemia viral oncogene homolog 2 | Abelson tyrosine-protein kinase 2 | Abelson-related gene protein | Tyrosine-protein kinase ARG
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family

Target Components

Component Description Relationship Accession
Abelson tyrosine-protein kinase 2 SINGLE PROTEIN P42684

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111414 Tyrosine-protein kinase ABL PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143322
Ensembl ENSG00000143322
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0015629 (actin cytoskeleton)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003785 (actin monomer binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO:0051015 (actin filament binding)
GO Biological Process GO:0006464 (cellular protein modification process)
GO:0006468 (protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0010506 (regulation of autophagy)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0010976 (positive regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0030100 (regulation of endocytosis)
GO:0030155 (regulation of cell adhesion)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0071300 (cellular response to retinoic acid)
GO:2000145 (regulation of cell motility)
GO:2000249 (regulation of actin cytoskeleton reorganization)
Wikipedia ABL2

Target Cross References - Protein

canSAR P42684
Human Protein Atlas ENSG00000143322
IntAct P42684
Guide to Pharmacology 1924
Open Targets ENSG00000143322
PharmGKB PA24414
Pharos P42684 (Tchem)
Reactome R-HSA-428890 (Role of Abl in Robo-Slit signaling.)
UniProt A0M8X0 B7UEF2 B7UEF3 B7UEF4 B7UEF5 P42684 Q5T0X6 Q5W0C5 Q6NZY6 Q7Z301

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015015 (F-actin_binding.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
PF08919 (F_actin_bind)

Target Cross References - Structure

PDBe 2XYN 3GVU 3HMI 3ULR 4EIH
CREDO 2XYN 3GVU 3HMI 3ULR 4EIH
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