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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4003
Target Type SINGLE PROTEIN
Preferred Name Histidase
Synonyms HAL | HIS | Histidase | Histidine ammonia-lyase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Histidine ammonia-lyase SINGLE PROTEIN P42357

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000084110
Ensembl ENSG00000084110
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004397 (histidine ammonia-lyase activity)
GO:0016829 (lyase activity)
GO:0016841 (ammonia-lyase activity)
GO Biological Process GO:0006547 (histidine metabolic process)
GO:0006548 (histidine catabolic process)
GO:0019556 (histidine catabolic process to glutamate and formamide)
GO:0019557 (histidine catabolic process to glutamate and formate)
Wikipedia Histidine_ammonia-lyase

Target Cross References - Protein

canSAR P42357
CGD Histidinemia
Human Protein Atlas ENSG00000084110
IntAct P42357
Open Targets ENSG00000084110
PharmGKB PA29181
Reactome R-HSA-70921 (Histidine catabolism.)
UniProt B4DQC1 B4E0V8 F5GXF2 F5H1U5 P42357 Q4VB92 Q4VB93

Target Cross References - Domain

InterPro IPR001106 (Aromatic_Lyase.)
IPR005921 (HutH.)
IPR008948 (L-Aspartase-like.)
IPR022313 (Phe/His_NH3-lyase_AS.)
IPR024083 (Fumarase/histidase_N.)
Pfam PF00221 (Lyase_aromatic)
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