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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3991
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor VII
Synonyms Coagulation factor VII | F7 | Factor VII heavy chain | Factor VII light chain | INN=Eptacog alfa | Proconvertin | SPCA | Serum prothrombin conversion accelerator
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Coagulation factor VII SINGLE PROTEIN P08709

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111477 Thrombin and coagulation factor VII SELECTIVITY GROUP
CHEMBL2111412 Coagulation factor VII and X SELECTIVITY GROUP
CHEMBL2095194 Coagulation factor VII/tissue factor PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000057593
Ensembl ENSG00000057593
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO:0031982 (vesicle)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005102 (receptor binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0002690 (positive regulation of leukocyte chemotaxis)
GO:0006465 (signal peptide processing)
GO:0006508 (proteolysis)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0007596 (blood coagulation)
GO:0007598 (blood coagulation, extrinsic pathway)
GO:0007599 (hemostasis)
GO:0007623 (circadian rhythm)
GO:0009725 (response to hormone)
GO:0010641 (positive regulation of platelet-derived growth factor receptor signaling pathway)
GO:0014070 (response to organic cyclic compound)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0030194 (positive regulation of blood coagulation)
GO:0030335 (positive regulation of cell migration)
GO:0031100 (organ regeneration)
GO:0031667 (response to nutrient levels)
GO:0032571 (response to vitamin K)
GO:0043627 (response to estrogen)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060416 (response to growth hormone)
Wikipedia Factor_VII

Target Cross References - Protein

canSAR P08709
CGD Factor VII deficiency
Human Protein Atlas ENSG00000057593
IntAct P08709
Guide to Pharmacology 2363
Open Targets ENSG00000057593
PharmGKB PA160
Reactome R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-140834 (Extrinsic Pathway of Fibrin Clot Formation.)
R-HSA-159740 (Gamma-carboxylation of protein precursors.)
R-HSA-159763 (Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.)
R-HSA-159782 (Removal of aminoterminal propeptides from gamma-carboxylated proteins.)
UniProt B0YJC8 P08709 Q14339 Q5JVF1 Q5JVF2 Q9UD52 Q9UD53 Q9UD54

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000294 (GLA_domain.)
IPR000742 (EGF-like_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR012224 (Pept_S1A_FX.)
IPR013032 (EGF-like_CS.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018097 (EGF_Ca-bd_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
IPR033190 (F7.)
Pfam PF00008 (EGF)
PF00089 (Trypsin)
PF00594 (Gla)

Target Cross References - Structure

PDBe 1CVW 1DAN 1DVA 1FAK 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER More...
CREDO 1CVW 1DAN 1DVA 1FAK 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER More...
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