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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3981
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase 10
Synonyms LOK | Lymphocyte-oriented kinase | STK10 | Serine/threonine-protein kinase 10
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase slk subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 10 SINGLE PROTEIN O94804

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000072786
Ensembl ENSG00000072786
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0035579 (specific granule membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0032147 (activation of protein kinase activity)
GO:0042981 (regulation of apoptotic process)
GO:0043312 (neutrophil degranulation)
GO:0046777 (protein autophosphorylation)
GO:0071593 (lymphocyte aggregation)
GO:2000401 (regulation of lymphocyte migration)
Wikipedia STK10

Target Cross References - Protein

canSAR O94804
Human Protein Atlas ENSG00000072786
IntAct O94804
Guide to Pharmacology 2211
Open Targets ENSG00000072786
PharmGKB PA36197
Pharos O94804 (Tchem)
Reactome R-HSA-6798695 (Neutrophil degranulation.)
UniProt A6ND35 B2R8F5 B3KMY1 O94804 Q6NSK0 Q9UIW4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR022165 (PKK.)
Pfam PF00069 (Pkinase)
PF12474 (PKK)

Target Cross References - Structure

PDBe 2J7T 4AOT 4BC6 4EQU 4USD 4USE 5AJQ 5OWQ 5OWR 6EIM
CREDO 2J7T 4AOT 4BC6 4EQU 4USD 4USE 5AJQ 5OWQ 5OWR 6EIM
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