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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3979
Target Type SINGLE PROTEIN
Preferred Name Peroxisome proliferator-activated receptor delta
Synonyms NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR-beta | PPAR-delta | PPARB | PPARD | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group c > nuclear hormone receptor subfamily 1 group c member 2

Target Components

Component Description Relationship Accession
Peroxisome proliferator-activated receptor delta SINGLE PROTEIN Q03181

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111371 PPAR delta/gamma SELECTIVITY GROUP
CHEMBL3559683 Peroxisome proliferator-activated receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545019 MBX-8025 Peroxisome proliferator-activated receptor delta agonist 2 Other PubMed
CHEMBL3544958 CER-002 Peroxisome proliferator-activated receptor delta agonist 1 Other PubMed
CHEMBL3545114 KD3010 Peroxisome proliferator-activated receptor delta agonist 1 Other PubMed
CHEMBL3545176 DB959 Peroxisome proliferator-activated receptor delta agonist 1 Other Other
CHEMBL3545295 AVE0847 Peroxisome proliferator-activated receptor delta agonist 1 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112033
Ensembl ENSG00000112033
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0001227 (transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005504 (fatty acid binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0051059 (NF-kappaB binding)
GO:0070539 (linoleic acid binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001890 (placenta development)
GO:0006006 (glucose metabolic process)
GO:0006029 (proteoglycan metabolic process)
GO:0006091 (generation of precursor metabolites and energy)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006629 (lipid metabolic process)
GO:0006635 (fatty acid beta-oxidation)
GO:0006776 (vitamin A metabolic process)
GO:0006915 (apoptotic process)
GO:0007507 (heart development)
GO:0007566 (embryo implantation)
GO:0008203 (cholesterol metabolic process)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008366 (axon ensheathment)
GO:0008654 (phospholipid biosynthetic process)
GO:0009062 (fatty acid catabolic process)
GO:0009299 (mRNA transcription)
GO:0009749 (response to glucose)
GO:0010033 (response to organic substance)
GO:0010628 (positive regulation of gene expression)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0014823 (response to activity)
GO:0014842 (regulation of skeletal muscle satellite cell proliferation)
GO:0014912 (negative regulation of smooth muscle cell migration)
GO:0015758 (glucose transport)
GO:0015908 (fatty acid transport)
GO:0019395 (fatty acid oxidation)
GO:0030154 (cell differentiation)
GO:0030308 (negative regulation of cell growth)
GO:0030522 (intracellular receptor signaling pathway)
GO:0031589 (cell-substrate adhesion)
GO:0032024 (positive regulation of insulin secretion)
GO:0032966 (negative regulation of collagen biosynthetic process)
GO:0033189 (response to vitamin A)
GO:0042060 (wound healing)
GO:0042127 (regulation of cell proliferation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043415 (positive regulation of skeletal muscle tissue regeneration)
GO:0043616 (keratinocyte proliferation)
GO:0045598 (regulation of fat cell differentiation)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045662 (negative regulation of myoblast differentiation)
GO:0045684 (positive regulation of epidermis development)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045909 (positive regulation of vasodilation)
GO:0046697 (decidualization)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0050728 (negative regulation of inflammatory response)
GO:0051546 (keratinocyte migration)
GO:0060612 (adipose tissue development)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071456 (cellular response to hypoxia)
GO:0097190 (apoptotic signaling pathway)
GO:1902894 (negative regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:2000288 (positive regulation of myoblast proliferation)
Wikipedia Peroxisome_proliferator-activated_receptor_delta

Target Cross References - Protein

canSAR Q03181
Human Protein Atlas ENSG00000112033
IntAct Q03181
Guide to Pharmacology 594
Open Targets ENSG00000112033
PharmGKB PA33557
Pharos Q03181 (Tchem)
Reactome R-HSA-200425 (Import of palmitoyl-CoA into the mitochondrial matrix.)
R-HSA-204174 (Regulation of pyruvate dehydrogenase (PDH) complex.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5362517 (Signaling by Retinoic Acid.)
UniProt A8K6J6 B4E3V3 B6ZGS1 B7Z3W1 E9PE18 Q03181 Q5D1P0 Q7Z5K0 Q9BUD4

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003074 (1Cnucl_rcpt.)
IPR003075 (1Cnucl_rcpt_B.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1GWX 1Y0S 2AWH 2B50 2BAW 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM
CREDO 1GWX 1Y0S 2AWH 2B50 2BAW 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM
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