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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3973
Target Type SINGLE PROTEIN
Preferred Name Fibroblast growth factor receptor 4
Synonyms CD_antigen=CD334 | FGFR-4 | FGFR4 | Fibroblast growth factor receptor 4 | JTK2 | TKF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fgfr family

Target Components

Component Description Relationship Accession
Fibroblast growth factor receptor 4 SINGLE PROTEIN P22455

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095217 Fibroblast growth factor receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545293 FGF401 Fibroblast growth factor receptor 4 inhibitor 2 ClinicalTrials Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160867
Ensembl ENSG00000160867
GO Cellular Component GO:0005576 (extracellular region)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030133 (transport vesicle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005007 (fibroblast growth factor-activated receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008201 (heparin binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0017134 (fibroblast growth factor binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0010628 (positive regulation of gene expression)
GO:0010715 (regulation of extracellular matrix disassembly)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019216 (regulation of lipid metabolic process)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0042593 (glucose homeostasis)
GO:0043085 (positive regulation of catalytic activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0045862 (positive regulation of proteolysis)
GO:0046777 (protein autophosphorylation)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0055062 (phosphate ion homeostasis)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070857 (regulation of bile acid biosynthetic process)
GO:1903412 (response to bile acid)
GO:2000188 (regulation of cholesterol homeostasis)
GO:2000573 (positive regulation of DNA biosynthetic process)
Wikipedia Fibroblast_growth_factor_receptor_4

Target Cross References - Protein

canSAR P22455
Human Protein Atlas ENSG00000160867
IntAct P22455
Guide to Pharmacology 1811
Open Targets ENSG00000160867
PharmGKB PA28130
Pharos P22455 (Tclin)
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1307965 (betaKlotho-mediated ligand binding.)
R-HSA-1839128 (FGFR4 mutant receptor activation.)
R-HSA-190322 (FGFR4 ligand binding and activation.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-5654228 (Phospholipase C-mediated cascade, FGFR4.)
R-HSA-5654712 (FRS-mediated FGFR4 signaling.)
R-HSA-5654719 (SHC-mediated cascade:FGFR4.)
R-HSA-5654720 (PI-3K cascade:FGFR4.)
R-HSA-5654733 (Negative regulation of FGFR4 signaling.)
R-HSA-5655291 (Signaling by FGFR4 in disease.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
UniProt G3JVM2 G3JVM5 G3JVM7 G3JVM9 O43785 P22455 Q14309 Q71TW8 Q8TDA0 Q96KE5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR016248 (FGF_rcpt_fam.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG
CREDO 4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG
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