ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3972
Target Type SINGLE PROTEIN
Preferred Name GAR transformylase
Synonyms 5'-phosphoribosylglycinamide transformylase | AIR synthase | AIRS | GAR transformylase | GARS | GART | GART | Glycinamide ribonucleotide synthetase | PGFT | PRGS | Phosphoribosyl-aminoimidazole synthetase | Phosphoribosylamine--glycine ligase | Phosphoribosylformylglycinamidine cyclo-ligase | Phosphoribosylglycinamide formyltransferase | Phosphoribosylglycinamide synthetase | Trifunctional purine biosynthetic protein adenosine-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > ligase

Target Components

Component Description Relationship Accession
Trifunctional purine biosynthetic protein adenosine-3 SINGLE PROTEIN P22102

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430882 GAR transformylase/AICAR transformylase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200373 PEMETREXED DISODIUM GAR transformylase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000159131 ENSG00000262473
Ensembl ENSG00000159131 ENSG00000262473
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004637 (phosphoribosylamine-glycine ligase activity)
GO:0004641 (phosphoribosylformylglycinamidine cyclo-ligase activity)
GO:0004644 (phosphoribosylglycinamide formyltransferase activity)
GO:0005524 (ATP binding)
GO:0016740 (transferase activity)
GO:0016742 (hydroxymethyl-, formyl- and related transferase activity)
GO:0016874 (ligase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0003360 (brainstem development)
GO:0006164 (purine nucleotide biosynthetic process)
GO:0006189 (de novo IMP biosynthetic process)
GO:0006544 (glycine metabolic process)
GO:0008152 (metabolic process)
GO:0009058 (biosynthetic process)
GO:0009113 (purine nucleobase biosynthetic process)
GO:0009156 (ribonucleoside monophosphate biosynthetic process)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0010033 (response to organic substance)
GO:0010035 (response to inorganic substance)
GO:0021549 (cerebellum development)
GO:0021987 (cerebral cortex development)
GO:0046654 (tetrahydrofolate biosynthetic process)
Wikipedia Trifunctional_purine_biosynthetic_protein_adenosine-3

Target Cross References - Protein

canSAR P22102
Human Protein Atlas ENSG00000159131 ENSG00000262473
IntAct P22102
Open Targets ENSG00000159131 ENSG00000262473
PharmGKB PA28576
Reactome R-HSA-73817 (Purine ribonucleoside monophosphate biosynthesis.)
UniProt A8K945 A8KA32 D3DSF3 D3DSF4 O14659 P22102 Q52M77

Target Cross References - Domain

InterPro IPR000115 (PRibGlycinamide_synth.)
IPR001555 (GART_AS.)
IPR002376 (Formyl_transf_N.)
IPR004607 (GART.)
IPR004733 (PurM_cligase.)
IPR010918 (AIR_synth_C_dom.)
IPR011054 (Rudment_hybrid_motif.)
IPR011761 (ATP-grasp.)
IPR013815 (ATP_grasp_subdomain_1.)
IPR013816 (ATP_grasp_subdomain_2.)
IPR016185 (PreATP-grasp_dom.)
IPR016188 (PurM-like_N.)
IPR020559 (PRibGlycinamide_synth_CS.)
IPR020560 (PRibGlycinamide_synth_C-dom.)
IPR020561 (PRibGlycinamid_synth_ATP-grasp.)
IPR020562 (PRibGlycinamide_synth_N.)
Pfam PF00551 (Formyl_trans_N)
PF00586 (AIRS)
PF01071 (GARS_A)
PF02769 (AIRS_C)
PF02843 (GARS_C)
PF02844 (GARS_N)

Target Cross References - Structure

PDBe 1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 2QK4 2V9Y 4EW1 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ More...
CREDO 1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 2QK4 2V9Y 4EW1 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ More...
spacer
spacer