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Target Report Card

Target Name and Classification

Target ID CHEMBL3956
Preferred Name Mitogen-activated protein kinase kinase kinase 1
Synonyms MAP3K1 | MAPK/ERK kinase kinase 1 | MAPKKK1 | MEK kinase 1 | MEKK 1 | MEKK | MEKK1 | Mitogen-activated protein kinase kinase kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 1 SINGLE PROTEIN Q13233

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1097999 E-6201 Mitogen-activated protein kinase kinase kinase 1 inhibitor 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000095015
Ensembl ENSG00000095015
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004672 (protein kinase activity)
GO:0004706 (JUN kinase kinase kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0003382 (epithelial cell morphogenesis)
GO:0006468 (protein phosphorylation)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007257 (activation of JUN kinase activity)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008063 (Toll signaling pathway)
GO:0008637 (apoptotic mitochondrial changes)
GO:0030334 (regulation of cell migration)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0032147 (activation of protein kinase activity)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0034146 (toll-like receptor 5 signaling pathway)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0034166 (toll-like receptor 10 signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038123 (toll-like receptor TLR1:TLR2 signaling pathway)
GO:0038124 (toll-like receptor TLR6:TLR2 signaling pathway)
GO:0042060 (wound healing)
GO:0042981 (regulation of apoptotic process)
GO:0045087 (innate immune response)
GO:0051403 (stress-activated MAPK cascade)
GO:0061029 (eyelid development in camera-type eye)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia MAP3K1

Target Cross References - Protein

canSAR Q13233
CGD 46,XY Sex Reversal 6
Human Protein Atlas ENSG00000095015
IntAct Q13233
PharmGKB PA30592
UniProt Q13233

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR001841 (Znf_RING.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR007527 (Znf_SWIM.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR016024 (ARM-type_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)