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Target Report Card

Target Name and Classification

Target ID CHEMBL3956
Preferred Name Mitogen-activated protein kinase kinase kinase 1
Synonyms MAP3K1 | MAPK/ERK kinase kinase 1 | MAPKKK1 | MEK kinase 1 | MEKK 1 | MEKK | MEKK1 | Mitogen-activated protein kinase kinase kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste11 family

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 1 SINGLE PROTEIN Q13233

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1097999 E-6201 Mitogen-activated protein kinase kinase kinase 1 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000095015
Ensembl ENSG00000095015
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0032147 (activation of protein kinase activity)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042981 (regulation of apoptotic process)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia MAP3K1

Target Cross References - Protein

canSAR Q13233
CGD 46,XY Sex Reversal 6
Human Protein Atlas ENSG00000095015
IntAct Q13233
Guide to Pharmacology 2069
Open Targets ENSG00000095015
PharmGKB PA30592
Pharos Q13233 (Tbio)
Reactome R-HSA-166058 (MyD88:Mal cascade initiated on plasma membrane.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
R-HSA-975138 (TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.)
R-HSA-975871 (MyD88 cascade initiated on plasma membrane.)
UniProt Q13233

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001841 (Znf_RING.)
IPR007527 (Znf_SWIM.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011989 (ARM-like.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR016024 (ARM-type_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)