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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3955
Target Type SINGLE PROTEIN
Preferred Name Fibronectin receptor alpha
Synonyms CD49 antigen-like family member E | CD_antigen=CD49e | FNRA | Fibronectin receptor subunit alpha | ITGA5 | Integrin alpha-5 heavy chain | Integrin alpha-5 light chain | Integrin alpha-5 | Integrin alpha-F | VLA-5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-5 SINGLE PROTEIN P08648

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111425 Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) PROTEIN COMPLEX GROUP
CHEMBL2095226 Integrin alpha-5/beta-1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000161638
Ensembl ENSG00000161638
GO Cellular Component GO:0001726 (ruffle)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0032587 (ruffle membrane)
GO:0045202 (synapse)
GO:0071062 (alphav-beta3 integrin-vitronectin complex)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0043184 (vascular endothelial growth factor receptor 2 binding)
GO:0046872 (metal ion binding)
GO:0050839 (cell adhesion molecule binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0007044 (cell-substrate junction assembly)
GO:0007155 (cell adhesion)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007613 (memory)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0016032 (viral process)
GO:0030198 (extracellular matrix organization)
GO:0030335 (positive regulation of cell migration)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0031589 (cell-substrate adhesion)
GO:0033631 (cell-cell adhesion mediated by integrin)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0035313 (wound healing, spreading of epidermal cells)
GO:0035987 (endodermal cell differentiation)
GO:0046718 (viral entry into host cell)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050900 (leukocyte migration)
GO:1903672 (positive regulation of sprouting angiogenesis)
GO:2000811 (negative regulation of anoikis)
Wikipedia ITGA5

Target Cross References - Protein

canSAR P08648
Human Protein Atlas ENSG00000161638
IntAct P08648
Open Targets ENSG00000161638
PharmGKB PA29941
Reactome R-HSA-1566948 (Elastic fibre formation.)
R-HSA-1566977 (Fibronectin matrix formation.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-445144 (Signal transduction by L1.)
TIMBAL Integrins
UniProt P08648 Q96HA5

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR032695 (Integrin_dom.)
Pfam PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 3VI3 3VI4 4WJK 4WK0 4WK2 4WK4
CREDO 3VI3 3VI4 4WJK 4WK0 4WK2 4WK4
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