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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3955
Preferred Name Fibronectin receptor alpha
Synonyms CD49 antigen-like family member E | CD_antigen=CD49e | FNRA | Fibronectin receptor subunit alpha | ITGA5 | Integrin alpha-5 | Integrin alpha-5 heavy chain | Integrin alpha-5 light chain | Integrin alpha-F | VLA-5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-5 SINGLE PROTEIN P08648

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095226 Integrin alpha-5/beta-1 PROTEIN COMPLEX
CHEMBL2111425 Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000161638
Ensembl ENSG00000161638
GO Cellular Component GO:0001726 (ruffle)
GO:0008305 (integrin complex)
GO:0071062 (alphav-beta3 integrin-vitronectin complex)
GO Molecular Function GO:0004872 (receptor activity)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0043184 (vascular endothelial growth factor receptor 2 binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007411 (axon guidance)
GO:0007596 (blood coagulation)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0035313 (wound healing, spreading of epidermal cells)
GO:0044419 (interspecies interaction between organisms)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050900 (leukocyte migration)
Wikipedia ITGA5

Target Cross References - Protein

canSAR P08648
Human Protein Atlas ENSG00000161638
IntAct P08648
Guide to Pharmacology 2444 (integrin, alpha 5 subunit (fibronectin receptor, alpha polypeptide))
PharmGKB PA29941
Reactome REACT_13552 (Integrin cell surface interactions.)
REACT_18266 (Axon guidance.)
REACT_604 (Hemostasis.)
TIMBAL Integrins
UniProt P08648 Q96HA5

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
Pfam PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)