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Target Report Card

Target Name and Classification

Target ID CHEMBL3924
Target Type SINGLE PROTEIN
Preferred Name Dual specificity phosphatase 22
Synonyms DUSP22 | Dual specificity protein phosphatase 22 | JNK-stimulatory phosphatase-1 | JSP-1 | JSP1 | LMW-DSP2 | LMWDSP2 | Low molecular weight dual specificity phosphatase 2 | MAP kinase phosphatase x | MKP-x | MKPX | Mitogen-activated protein kinase phosphatase x
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine/tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Dual specificity protein phosphatase 22 SINGLE PROTEIN Q9NRW4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112679
Ensembl ENSG00000112679
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0008138 (protein tyrosine/serine/threonine phosphatase activity)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000188 (inactivation of MAPK activity)
GO:0002710 (negative regulation of T cell mediated immunity)
GO:0006470 (protein dephosphorylation)
GO:0006915 (apoptotic process)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0016311 (dephosphorylation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0046330 (positive regulation of JNK cascade)
GO:0050860 (negative regulation of T cell receptor signaling pathway)
GO:0050868 (negative regulation of T cell activation)
Wikipedia DUSP22

Target Cross References - Protein

canSAR Q9NRW4
Human Protein Atlas ENSG00000112679
IntAct Q9NRW4
Open Targets ENSG00000112679
PharmGKB PA134991025
UniProt B4DK56 Q59GW2 Q5VWR2 Q96AR1 Q9NRW4

Target Cross References - Domain

InterPro IPR000340 (Dual-sp_phosphatase_cat-dom.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR020417 (Atypical_DUSP.)
IPR020422 (TYR_PHOSPHATASE_DUAL_dom.)
IPR024950 (DUSP.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00782 (DSPc)

Target Cross References - Structure

PDBe 1WRM 4WOH
CREDO 1WRM 4WOH
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