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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL3920
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C theta
Synonyms PRKCQ | PRKCT | Protein kinase C theta type | nPKC-theta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc delta subfamily

Target Components

Component Description Relationship Accession
Protein kinase C theta type SINGLE PROTEIN Q04759

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065675
Ensembl ENSG00000065675
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031594 (neuromuscular junction)
GO:0042383 (sarcolemma)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0001666 (response to hypoxia)
GO:0002376 (immune system process)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0006954 (inflammatory response)
GO:0007411 (axon guidance)
GO:0007568 (aging)
GO:0009408 (response to heat)
GO:0009749 (response to glucose)
GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
GO:0014070 (response to organic cyclic compound)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019229 (regulation of vasoconstriction)
GO:0030168 (platelet activation)
GO:0030182 (neuron differentiation)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0032868 (response to insulin)
GO:0035556 (intracellular signal transduction)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042246 (tissue regeneration)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0045086 (positive regulation of interleukin-2 biosynthetic process)
GO:0045730 (respiratory burst)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0050714 (positive regulation of protein secretion)
GO:0050852 (T cell receptor signaling pathway)
GO:0050870 (positive regulation of T cell activation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051491 (positive regulation of filopodium assembly)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051973 (positive regulation of telomerase activity)
GO:0060326 (cell chemotaxis)
GO:0070233 (negative regulation of T cell apoptotic process)
GO:0090330 (regulation of platelet aggregation)
GO:1904355 (positive regulation of telomere capping)
GO:2000318 (positive regulation of T-helper 17 type immune response)
GO:2000570 (positive regulation of T-helper 2 cell activation)
Wikipedia PRKCQ

Target Cross References - Protein

canSAR Q04759
Human Protein Atlas ENSG00000065675
IntAct Q04759
Guide to Pharmacology 1488
Open Targets ENSG00000065675
PharmGKB PA33773
Pharos Q04759 (Tchem)
Reactome R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-114508 (Effects of PIP2 hydrolysis.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-373752 (Netrin-1 signaling.)
R-HSA-418597 (G alpha (z) signalling events.)
UniProt B4DF52 Q04759 Q14DH6 Q3MJF1 Q64FY5 Q9H508 Q9H549

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014376 (Prot_kin_PKC_delta.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
IPR027264 (PKC_theta.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 1XJD 2JED 4Q9Z 4RA5
CREDO 1XJD 2JED 4Q9Z 4RA5
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