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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3913
Target Type SINGLE PROTEIN
Preferred Name Complement C1s
Synonyms C1 esterase | C1S | Complement C1s subcomponent heavy chain | Complement C1s subcomponent light chain | Complement C1s subcomponent | Complement component 1 subcomponent s
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Complement C1s subcomponent SINGLE PROTEIN P09871

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182326
Ensembl ENSG00000182326
GO Cellular Component GO:0005576 (extracellular region)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002376 (immune system process)
GO:0006508 (proteolysis)
GO:0006956 (complement activation)
GO:0006958 (complement activation, classical pathway)
GO:0045087 (innate immune response)
Wikipedia C1S

Target Cross References - Protein

canSAR P09871
CGD Complement component C1s deficiency
Human Protein Atlas ENSG00000182326
IntAct P09871
Guide to Pharmacology 2335
Open Targets ENSG00000182326
PharmGKB PA25636
Reactome R-HSA-166663 (Initial triggering of complement.)
R-HSA-173623 (Classical antibody-mediated complement activation.)
UniProt D3DUT4 P09871 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000436 (Sushi_SCR_CCP_dom.)
IPR000859 (CUB_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR018097 (EGF_Ca-bd_CS.)
IPR024175 (Pept_S1A_C1r/C1S/mannan-bd.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00084 (Sushi)
PF00089 (Trypsin)
PF00431 (CUB)

Target Cross References - Structure

PDBe 1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT
CREDO 1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT
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