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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3906
Target Type SINGLE PROTEIN
Preferred Name Ribosomal protein S6 kinase alpha 2
Synonyms 90 kDa ribosomal protein S6 kinase 2 | MAP kinase-activated protein kinase 1c | MAPK-activated protein kinase 1c | MAPKAP kinase 1c | MAPKAPK-1c | MAPKAPK1C | RPS6KA2 | RSK-3 | RSK3 | Ribosomal S6 kinase 3 | Ribosomal protein S6 kinase alpha-2 | S6K-alpha-2 | p90-RSK 2 | p90RSK2 | pp90RSK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase rskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase rsk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-2 SINGLE PROTEIN Q15349

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000071242
Ensembl ENSG00000071242
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004711 (ribosomal protein S6 kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001556 (oocyte maturation)
GO:0002035 (brain renin-angiotensin system)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007507 (heart development)
GO:0008285 (negative regulation of cell proliferation)
GO:0010628 (positive regulation of gene expression)
GO:0010659 (cardiac muscle cell apoptotic process)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0045786 (negative regulation of cell cycle)
GO:0045835 (negative regulation of meiotic nuclear division)
GO:0060047 (heart contraction)
GO:0070613 (regulation of protein processing)
GO:0071322 (cellular response to carbohydrate stimulus)
Wikipedia RPS6KA2

Target Cross References - Protein

canSAR Q15349
Human Protein Atlas ENSG00000071242
IntAct Q15349
Guide to Pharmacology 1529
Open Targets ENSG00000071242
PharmGKB PA34846
Pharos Q15349 (Tchem)
Reactome R-HSA-198753 (ERK/MAPK targets.)
R-HSA-199920 (CREB phosphorylation.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-437239 (Recycling pathway of L1.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-444257 (RSK activation.)
R-HSA-881907 (Gastrin-CREB signalling pathway via PKC and MAPK.)
UniProt B3KTK9 Q15349 Q15419 Q59GJ3 Q5TI68 Q96J38 Q9UJN5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)
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