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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3905
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase Lyn
Synonyms JTK8 | LYN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Lyn SINGLE PROTEIN P07948

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL288441 BOSUTINIB Tyrosine-protein kinase Lyn inhibitor Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000249529
Ensembl ENSG00000249529
GO Cellular Component GO:0005634 (nucleus)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0044325 (ion channel binding)
GO Biological Process GO:0006974 (response to DNA damage stimulus)
GO:0030168 (platelet activation)
GO:0030218 (erythrocyte differentiation)
GO:0031295 (T cell costimulation)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0044419 (interspecies interaction between organisms)
GO:0050900 (leukocyte migration)
GO:0051272 (positive regulation of cellular component movement)
GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade)
Wikipedia LYN

Target Cross References - Protein

canSAR P07948
Human Protein Atlas ENSG00000249529
IntAct P07948
Guide to Pharmacology 2060 (LYN proto-oncogene, Src family tyrosine kinase)
PharmGKB PA30498
Reactome REACT_604 (Hemostasis.)
REACT_6900 (Signaling in Immune system.)
UniProt A0AVQ5 P07948

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3A4O
CREDO 3A4O
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