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Target Report Card

Target Name and Classification

Target ID CHEMBL3904
Preferred Name Inositol 1,4,5-trisphosphate receptor type 3
Synonyms IP3 receptor isoform 3 | IP3R 3 | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 | InsP3R3 | Type 3 InsP3 receptor | Type 3 inositol 1,4,5-trisphosphate receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ip3 receptor

Target Components

Component Description Relationship Accession
Inositol 1,4,5-trisphosphate receptor type 3 SINGLE PROTEIN Q14573

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111451 Inositol 1,4,5-trisphosphate receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000096433
Ensembl ENSG00000096433
GO Cellular Component GO:0005634 (nucleus)
GO:0005640 (nuclear outer membrane)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005903 (brush border)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031095 (platelet dense tubular network membrane)
GO:0043025 (neuronal cell body)
GO:0043209 (myelin sheath)
GO:0043235 (receptor complex)
GO:0045177 (apical part of cell)
GO Molecular Function GO:0000822 (inositol hexakisphosphate binding)
GO:0005216 (ion channel activity)
GO:0005220 (inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)
GO:0005262 (calcium channel activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0015278 (calcium-release channel activity)
GO:0035091 (phosphatidylinositol binding)
GO:0043533 (inositol 1,3,4,5 tetrakisphosphate binding)
GO:0070679 (inositol 1,4,5 trisphosphate binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007613 (memory)
GO:0030168 (platelet activation)
GO:0048016 (inositol phosphate-mediated signaling)
GO:0050796 (regulation of insulin secretion)
GO:0050913 (sensory perception of bitter taste)
GO:0050916 (sensory perception of sweet taste)
GO:0050917 (sensory perception of umami taste)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051260 (protein homooligomerization)
GO:0051291 (protein heterooligomerization)
GO:0051592 (response to calcium ion)
GO:0055085 (transmembrane transport)
GO:0060291 (long-term synaptic potentiation)
GO:0060402 (calcium ion transport into cytosol)
GO:0070588 (calcium ion transmembrane transport)
GO:1903779 (regulation of cardiac conduction)
Wikipedia ITPR3

Target Cross References - Protein

canSAR Q14573
Human Protein Atlas ENSG00000096433
IntAct Q14573
Open Targets ENSG00000096433
PharmGKB PA29980
Pharos Q14573 (Tchem)
Reactome R-HSA-112043 (PLC beta mediated events.)
R-HSA-114508 (Effects of PIP2 hydrolysis.)
R-HSA-139853 (Elevation of cytosolic Ca2+ levels.)
R-HSA-1489509 (DAG and IP3 signaling.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5607763 (CLEC7A (Dectin-1) induces NFAT activation.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt Q14573 Q14649 Q5TAQ2

Target Cross References - Domain

InterPro IPR000493 (InsP3_rcpt.)
IPR000699 (RIH_dom.)
IPR005821 (Ion_trans_dom.)
IPR013662 (RIH_assoc-dom.)
IPR014821 (Ins145_P3_rcpt.)
IPR015925 (Ryanodine_recept-rel.)
IPR016093 (MIR_motif.)
IPR035910 (RyR/IP3R_RIH_dom_sf.)
IPR036300 (MIR_dom_sf.)
Pfam PF00520 (Ion_trans)
PF02815 (MIR)
PF08454 (RIH_assoc)
PF08709 (Ins145_P3_rec)