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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3900
Target Type SINGLE PROTEIN
Preferred Name Leukocyte proteinase 3
Synonyms AGP7 | C-ANCA antigen | Leukocyte proteinase 3 | MBN | Myeloblastin | NP-4 | Neutrophil proteinase 4 | P29 | PR-3 | PR3 | PRTN3 | Wegener autoantigen
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Myeloblastin SINGLE PROTEIN P24158

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196415 ENSG00000277804
Ensembl ENSG00000196415 ENSG00000277804
GO Cellular Component GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007596 (blood coagulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0030574 (collagen catabolic process)
GO:0050765 (negative regulation of phagocytosis)
GO:0097029 (mature conventional dendritic cell differentiation)
Wikipedia Proteinase_3

Target Cross References - Protein

canSAR P24158
Human Protein Atlas ENSG00000196415 ENSG00000277804
IntAct P24158
Guide to Pharmacology 2401
Open Targets ENSG00000196415 ENSG00000277804
PharmGKB PA33842
Reactome R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-449147 (Signaling by Interleukins.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6803157 (Antimicrobial peptides.)
UniProt P15637 P18078 P24158 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1FUJ
CREDO 1FUJ
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